Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 417911..419004 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag O3Y_RS16160 Protein ID WP_000351248.1
Coordinates 418603..419004 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag O3Y_RS16155 Protein ID WP_001047169.1
Coordinates 417911..418603 (+) Length 231 a.a.

Genomic Context

O3Y_RS16115O3Y_RS20630O3Y_RS19860O3Y_RS19875O3Y_RS19880O3Y_RS16125O3Y_RS16130O3Y_RS16135O3Y_RS20420O3Y_RS16150O3Y_RS16155O3Y_RS16160O3Y_RS20335O3Y_RS16165O3Y_RS16170O3Y_RS16175O3Y_RS16180O3Y_RS16185O3Y_RS16200O3Y_RS16205O3Y_RS16145O3Y_RS16190O3Y_RS16195
Location: 413194..413571 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 413628..413742 (115 bp)
Type: Others
Protein ID: Protein_435
Location: 413691..413972 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 414138..414251 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 414200..414427 (228 bp)
Type: Others
Protein ID: Protein_438
Location: 414768..415100 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 415087..415401 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 415538..415972 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 416140..416295 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 417468..417774 (307 bp)
Type: Others
Protein ID: Protein_444
Location: 417911..418603 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 418603..419004 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 418974..419117 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419192..419605 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 419819..420070 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420060..420347 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 420475..420930 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421252..421404 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 422603..423271 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 423423..423710 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 416420..417400 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 421606..422103 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422100..422372 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS16115413194..413571+378WP_000411109.1hypothetical protein-
O3Y_RS20630413628..413742+115Protein_435acetyltransferase-
O3Y_RS19860413691..413972+282WP_001894453.1DUF1289 domain-containing protein-
O3Y_RS19875414138..414251+114WP_001889158.1hypothetical protein-
O3Y_RS19880414200..414427+228Protein_438DUF1289 domain-containing protein-
O3Y_RS16125414768..415100+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
O3Y_RS16130415087..415401+315WP_000071008.1DNA-binding transcriptional regulator-
O3Y_RS16135415538..415972+435WP_000256036.1GNAT family N-acetyltransferase-
O3Y_RS20420416140..416295+156WP_000751734.1hypothetical protein-
O3Y_RS16145416420..417400-981WP_000019370.1IS5-like element ISVch5 family transposase-
O3Y_RS16150417468..417774+307Protein_444CatB-related O-acetyltransferase-
O3Y_RS16155417911..418603+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
O3Y_RS16160418603..419004+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
O3Y_RS20335418974..419117+144WP_071908341.1DUF3265 domain-containing protein-
O3Y_RS16165419192..419605+414WP_000049417.1VOC family protein-
O3Y_RS16170419819..420070+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
O3Y_RS16175420060..420347+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
O3Y_RS16180420475..420930+456WP_001245327.1GNAT family N-acetyltransferase-
O3Y_RS16185421252..421404+153WP_001884520.1DUF645 family protein-
O3Y_RS16190421606..422103-498WP_000982260.1GNAT family N-acetyltransferase-
O3Y_RS16195422100..422372-273WP_000246253.1DUF1778 domain-containing protein-
O3Y_RS16200422603..423271+669WP_000043871.1hypothetical protein-
O3Y_RS16205423423..423710+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489
flankIS/Tn--416420..417400980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T26153 WP_000351248.1 NC_016945:418603-419004 [Vibrio cholerae IEC224]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T26153 NC_016945:418603-419004 [Vibrio cholerae IEC224]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT26153 WP_001047169.1 NC_016945:417911-418603 [Vibrio cholerae IEC224]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT26153 NC_016945:417911-418603 [Vibrio cholerae IEC224]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References