48150

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 348284..348822 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag IR04_RS01655 Protein ID WP_000802136.1
Coordinates 348284..348583 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag IR04_RS01660 Protein ID WP_001107719.1
Coordinates 348580..348822 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR04_RS01620 344219..344401 + 183 WP_000923182.1 DUF645 family protein -
IR04_RS01625 344601..345074 + 474 WP_001161076.1 GrpB family protein -
IR04_RS19240 345089..345181 + 93 WP_014378730.1 DUF3265 domain-containing protein -
IR04_RS01630 345223..345849 + 627 WP_000365424.1 LysE family translocator -
IR04_RS01635 345972..346670 + 699 WP_001890502.1 hypothetical protein -
IR04_RS19245 346680..346790 + 111 WP_079857360.1 DUF3265 domain-containing protein -
IR04_RS01645 347368..347547 + 180 WP_001883058.1 DUF645 family protein -
IR04_RS01650 347761..348156 + 396 WP_000870857.1 DUF3465 domain-containing protein -
IR04_RS01655 348284..348583 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IR04_RS01660 348580..348822 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
IR04_RS19055 349051..349629 + 579 WP_000110120.1 hypothetical protein -
IR04_RS19255 349651..349743 + 93 WP_014164112.1 DUF3265 domain-containing protein -
IR04_RS01675 350167..350850 + 684 WP_000877436.1 hypothetical protein -
IR04_RS01680 351064..351330 + 267 WP_000937852.1 hypothetical protein -
IR04_RS01685 351485..352084 + 600 WP_000429495.1 hypothetical protein -
IR04_RS01690 352365..353300 + 936 WP_000051985.1 restriction endonuclease -
IR04_RS19270 353266..353406 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..409892 105192
inside Integron - - 309780..409516 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T48150 WP_000802136.1 NZ_CP009041:c348583-348284 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T48150 NZ_CP009041:c348583-348284 [Vibrio cholerae O1 biovar El Tor]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT48150 WP_001107719.1 NZ_CP009041:c348822-348580 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT48150 NZ_CP009041:c348822-348580 [Vibrio cholerae O1 biovar El Tor]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References