Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 348284..348822 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag IR04_RS01655 Protein ID WP_000802136.1
Coordinates 348284..348583 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag IR04_RS01660 Protein ID WP_001107719.1
Coordinates 348580..348822 (-) Length 81 a.a.

Genomic Context

IR04_RS01620IR04_RS01625IR04_RS19240IR04_RS01630IR04_RS01635IR04_RS19245IR04_RS01645IR04_RS01650IR04_RS19055IR04_RS19255IR04_RS01675IR04_RS01680IR04_RS01685IR04_RS01690IR04_RS19270IR04_RS01655IR04_RS01660
Location: 344219..344401 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 344601..345074 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 345089..345181 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 345223..345849 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 345972..346670 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 346680..346790 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 347368..347547 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 347761..348156 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 349051..349629 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 349651..349743 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 350167..350850 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 351064..351330 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 351485..352084 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 352365..353300 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 353266..353406 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 348284..348583 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 348580..348822 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IR04_RS01620344219..344401+183WP_000923182.1DUF645 family protein-
IR04_RS01625344601..345074+474WP_001161076.1GrpB family protein-
IR04_RS19240345089..345181+93WP_014378730.1DUF3265 domain-containing protein-
IR04_RS01630345223..345849+627WP_000365424.1LysE family translocator-
IR04_RS01635345972..346670+699WP_001890502.1hypothetical protein-
IR04_RS19245346680..346790+111WP_079857360.1DUF3265 domain-containing protein-
IR04_RS01645347368..347547+180WP_001883058.1DUF645 family protein-
IR04_RS01650347761..348156+396WP_000870857.1DUF3465 domain-containing protein-
IR04_RS01655348284..348583-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IR04_RS01660348580..348822-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
IR04_RS19055349051..349629+579WP_000110120.1hypothetical protein-
IR04_RS19255349651..349743+93WP_014164112.1DUF3265 domain-containing protein-
IR04_RS01675350167..350850+684WP_000877436.1hypothetical protein-
IR04_RS01680351064..351330+267WP_000937852.1hypothetical protein-
IR04_RS01685351485..352084+600WP_000429495.1hypothetical protein-
IR04_RS01690352365..353300+936WP_000051985.1restriction endonuclease-
IR04_RS19270353266..353406+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..409892105192
insideIntegron--309780..40951699736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T48150 WP_000802136.1 NZ_CP009041:c348583-348284 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T48150 NZ_CP009041:c348583-348284 [Vibrio cholerae O1 biovar El Tor]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT48150 WP_001107719.1 NZ_CP009041:c348822-348580 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT48150 NZ_CP009041:c348822-348580 [Vibrio cholerae O1 biovar El Tor]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References