Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 361544..362084 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag ASZ79_RS15995 Protein ID WP_000277238.1
Coordinates 361544..361813 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag ASZ79_RS16000 Protein ID WP_001258569.1
Coordinates 361806..362084 (-) Length 93 a.a.

Genomic Context

ASZ79_RS15945ASZ79_RS15950ASZ79_RS15955ASZ79_RS15965ASZ79_RS15970ASZ79_RS20555ASZ79_RS20560ASZ79_RS15990ASZ79_RS16005ASZ79_RS20575ASZ79_RS20580ASZ79_RS16010ASZ79_RS16015ASZ79_RS16020ASZ79_RS16025ASZ79_RS16030ASZ79_RS20990ASZ79_RS20995ASZ79_RS16045ASZ79_RS15940ASZ79_RS15975ASZ79_RS15980ASZ79_RS15995ASZ79_RS16000
Location: 357034..357420 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 357477..357590 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 357539..357820 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 358078..358614 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 358751..359266 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 360575..360700 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 360716..360754 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 360950..361396 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 362370..362648 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 362900..363106 (207 bp)
Type: Others
Protein ID: Protein_347
Location: 363306..363407 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 363397..363783 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 363978..364229 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 364202..364351 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 364443..364685 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 364937..365215 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 365590..365733 (144 bp)
Type: Others
Protein ID: Protein_354
Location: 365787..365825 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 366037..366504 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 356548..356790 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 359416..359913 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 359910..360182 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 361544..361813 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 361806..362084 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS15940356548..356790-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ79_RS15945357034..357420+387WP_001015867.1NUDIX hydrolase-
ASZ79_RS15950357477..357590+114WP_001900214.1hypothetical protein-
ASZ79_RS15955357539..357820+282WP_001894429.1DUF1289 domain-containing protein-
ASZ79_RS15965358078..358614+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ79_RS15970358751..359266+516WP_001201509.1lipocalin family protein-
ASZ79_RS15975359416..359913-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ79_RS15980359910..360182-273WP_000246253.1DUF1778 domain-containing protein-
ASZ79_RS20555360575..360700+126WP_001900195.1DUF645 family protein-
ASZ79_RS20560360716..360754+39WP_106019118.1hypothetical protein-
ASZ79_RS15990360950..361396+447WP_000006157.1hypothetical protein-
ASZ79_RS15995361544..361813-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
ASZ79_RS16000361806..362084-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ASZ79_RS16005362370..362648+279WP_001921601.1DUF3709 domain-containing protein-
ASZ79_RS20575362900..363106+207Protein_347DUF3709 domain-containing protein-
ASZ79_RS20580363306..363407+102WP_001921603.1hypothetical protein-
ASZ79_RS16010363397..363783+387WP_000703163.1VOC family protein-
ASZ79_RS16015363978..364229+252WP_001890111.1TIGR03643 family protein-
ASZ79_RS16020364202..364351+150WP_071908333.1DUF3265 domain-containing protein-
ASZ79_RS16025364443..364685+243WP_000107461.1hypothetical protein-
ASZ79_RS16030364937..365215+279WP_000280324.1DUF3709 domain-containing protein-
ASZ79_RS20990365590..365733+144Protein_354DUF645 family protein-
ASZ79_RS20995365787..365825+39WP_082798268.1hypothetical protein-
ASZ79_RS16045366037..366504+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T58355 WP_000277238.1 NZ_CP013314:c361813-361544 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T58355 NZ_CP013314:c361813-361544 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT58355 WP_001258569.1 NZ_CP013314:c362084-361806 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT58355 NZ_CP013314:c362084-361806 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References