58355

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 361544..362084 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag ASZ79_RS15995 Protein ID WP_000277238.1
Coordinates 361544..361813 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag ASZ79_RS16000 Protein ID WP_001258569.1
Coordinates 361806..362084 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ79_RS15940 356548..356790 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ79_RS15945 357034..357420 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ79_RS15950 357477..357590 + 114 WP_001900214.1 hypothetical protein -
ASZ79_RS15955 357539..357820 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ79_RS15965 358078..358614 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ79_RS15970 358751..359266 + 516 WP_001201509.1 lipocalin family protein -
ASZ79_RS15975 359416..359913 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ79_RS15980 359910..360182 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ79_RS20555 360575..360700 + 126 WP_001900195.1 DUF645 family protein -
ASZ79_RS20560 360716..360754 + 39 WP_106019118.1 hypothetical protein -
ASZ79_RS15990 360950..361396 + 447 WP_000006157.1 hypothetical protein -
ASZ79_RS15995 361544..361813 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
ASZ79_RS16000 361806..362084 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ79_RS16005 362370..362648 + 279 WP_001921601.1 DUF3709 domain-containing protein -
ASZ79_RS20575 362900..363106 + 207 Protein_347 DUF3709 domain-containing protein -
ASZ79_RS20580 363306..363407 + 102 WP_001921603.1 hypothetical protein -
ASZ79_RS16010 363397..363783 + 387 WP_000703163.1 VOC family protein -
ASZ79_RS16015 363978..364229 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ79_RS16020 364202..364351 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ79_RS16025 364443..364685 + 243 WP_000107461.1 hypothetical protein -
ASZ79_RS16030 364937..365215 + 279 WP_000280324.1 DUF3709 domain-containing protein -
ASZ79_RS20990 365590..365733 + 144 Protein_354 DUF645 family protein -
ASZ79_RS20995 365787..365825 + 39 WP_082798268.1 hypothetical protein -
ASZ79_RS16045 366037..366504 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..468464 163764
inside Integron - - 309780..468088 158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T58355 WP_000277238.1 NZ_CP013314:c361813-361544 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T58355 NZ_CP013314:c361813-361544 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT58355 WP_001258569.1 NZ_CP013314:c362084-361806 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT58355 NZ_CP013314:c362084-361806 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References