230648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 912430..912928 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag LZM82_RS17975 Protein ID WP_000589156.1
Coordinates 912662..912928 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag LZM82_RS17970 Protein ID WP_000643598.1
Coordinates 912430..912675 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17925 (LZM82_17925) 907511..907897 - 387 WP_000703163.1 VOC family protein -
LZM82_RS17930 (LZM82_17930) 908054..908560 - 507 WP_000393074.1 hypothetical protein -
LZM82_RS17935 (LZM82_17935) 909082..909267 - 186 WP_001999468.1 hypothetical protein -
LZM82_RS17940 (LZM82_17940) 909334..909693 - 360 WP_001071541.1 VOC family protein -
LZM82_RS17945 (LZM82_17945) 909846..910850 - 1005 WP_000964920.1 LD-carboxypeptidase -
LZM82_RS17950 (LZM82_17950) 911066..911248 - 183 WP_000923182.1 DUF645 family protein -
LZM82_RS17955 (LZM82_17955) 911309..911437 - 129 WP_071908338.1 general secretion pathway protein GspI -
LZM82_RS17960 (LZM82_17960) 911427..911543 - 117 WP_086010881.1 DUF3265 domain-containing protein -
LZM82_RS17965 (LZM82_17965) 911540..912334 - 795 WP_001911581.1 hypothetical protein -
LZM82_RS17970 (LZM82_17970) 912430..912675 - 246 WP_000643598.1 hypothetical protein Antitoxin
LZM82_RS17975 (LZM82_17975) 912662..912928 - 267 WP_000589156.1 BrnT family toxin Toxin
LZM82_RS17980 (LZM82_17980) 912995..913123 - 129 WP_088124358.1 DUF3265 domain-containing protein -
LZM82_RS17985 (LZM82_17985) 913113..913775 - 663 WP_000960654.1 hypothetical protein -
LZM82_RS17990 (LZM82_17990) 913903..914370 - 468 WP_001289288.1 OsmC family protein -
LZM82_RS17995 (LZM82_17995) 914542..914673 - 132 WP_001883067.1 hypothetical protein -
LZM82_RS18000 (LZM82_18000) 915192..915470 - 279 WP_000280324.1 DUF3709 domain-containing protein -
LZM82_RS18005 (LZM82_18005) 915722..915964 - 243 WP_000107461.1 hypothetical protein -
LZM82_RS18010 (LZM82_18010) 916056..916205 - 150 WP_071908333.1 DUF3265 domain-containing protein -
LZM82_RS18015 (LZM82_18015) 916178..916429 - 252 WP_001890111.1 TIGR03643 family protein -
LZM82_RS18020 (LZM82_18020) 916624..917010 - 387 WP_000703163.1 VOC family protein -
LZM82_RS18025 (LZM82_18025) 917000..917101 - 102 WP_001921603.1 hypothetical protein -
LZM82_RS18030 (LZM82_18030) 917301..917399 - 99 WP_223225486.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T230648 WP_000589156.1 NZ_CP090400:c912928-912662 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T230648 NZ_CP125226:5666-5953 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT230648 WP_000643598.1 NZ_CP090400:c912675-912430 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT230648 NZ_CP125226:5940-6254 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References