Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1000116..1000675 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag K1T75_RS18350 Protein ID WP_000578476.1
Coordinates 1000397..1000675 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag K1T75_RS18345 Protein ID WP_000381183.1
Coordinates 1000116..1000400 (+) Length 95 a.a.

Genomic Context

K1T75_RS18345K1T75_RS18350K1T75_RS18305K1T75_RS18310K1T75_RS18315K1T75_RS18320K1T75_RS18325K1T75_RS18330K1T75_RS18950K1T75_RS18335K1T75_RS18340K1T75_RS18355K1T75_RS18955K1T75_RS18360K1T75_RS18365K1T75_RS18370K1T75_RS18960K1T75_RS18375K1T75_RS18380K1T75_RS18385K1T75_RS18390
Location: 1000116..1000400 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 1000397..1000675 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 995782..995871 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 995902..996600 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 996723..997349 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 997391..997483 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 997498..997971 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 998171..998353 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 998414..998551 (138 bp)
Type: Others
Protein ID: WP_001890145.1
Location: 998745..999341 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 999406..999867 (462 bp)
Type: Others
Protein ID: WP_001911578.1
Location: 1000826..1001239 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 1001314..1001430 (117 bp)
Type: Others
Protein ID: WP_086010882.1
Location: 1001427..1001906 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 1002119..1002742 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 1002948..1003373 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 1003520..1003669 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 1003642..1003893 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 1004088..1004291 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 1004548..1004934 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 1005091..1005597 (507 bp)
Type: Others
Protein ID: WP_000393074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K1T75_RS18305995782..995871-90WP_072606010.1DUF3265 domain-containing protein-
K1T75_RS18310995902..996600-699WP_001890502.1hypothetical protein-
K1T75_RS18315996723..997349-627WP_000365424.1LysE family translocator-
K1T75_RS18320997391..997483-93WP_014378730.1DUF3265 domain-containing protein-
K1T75_RS18325997498..997971-474WP_001161076.1GrpB family protein-
K1T75_RS18330998171..998353-183WP_000923182.1DUF645 family protein-
K1T75_RS18950998414..998551-138WP_001890145.1hypothetical protein-
K1T75_RS18335998745..999341-597WP_000255434.1hypothetical protein-
K1T75_RS18340999406..999867-462WP_001911578.1lipocalin family protein-
K1T75_RS183451000116..1000400+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
K1T75_RS183501000397..1000675+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
K1T75_RS183551000826..1001239-414WP_000049420.1VOC family protein-
K1T75_RS189551001314..1001430-117WP_086010882.1DUF3265 domain-containing protein-
K1T75_RS183601001427..1001906-480WP_000009888.1lecithin retinol acyltransferase family protein-
K1T75_RS183651002119..1002742-624WP_000247070.1DUF1349 domain-containing protein-
K1T75_RS183701002948..1003373-426WP_000415750.1hypothetical protein-
K1T75_RS189601003520..1003669-150WP_071908333.1DUF3265 domain-containing protein-
K1T75_RS183751003642..1003893-252WP_001890111.1TIGR03643 family protein-
K1T75_RS183801004088..1004291-204WP_001911580.1hypothetical protein-
K1T75_RS183851004548..1004934-387WP_000703163.1VOC family protein-
K1T75_RS183901005091..1005597-507WP_000393074.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932680..1039634106954
insideIntegron--933056..103279299736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T211918 WP_000578476.1 NZ_CP080466:1000397-1000675 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T211918 NZ_CP106849:c1110016-1109813 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT211918 WP_000381183.1 NZ_CP080466:1000116-1000400 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT211918 NZ_CP106849:c1110405-1110037 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References