211918

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1000116..1000675 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag K1T75_RS18350 Protein ID WP_000578476.1
Coordinates 1000397..1000675 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag K1T75_RS18345 Protein ID WP_000381183.1
Coordinates 1000116..1000400 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS18305 995782..995871 - 90 WP_072606010.1 DUF3265 domain-containing protein -
K1T75_RS18310 995902..996600 - 699 WP_001890502.1 hypothetical protein -
K1T75_RS18315 996723..997349 - 627 WP_000365424.1 LysE family translocator -
K1T75_RS18320 997391..997483 - 93 WP_014378730.1 DUF3265 domain-containing protein -
K1T75_RS18325 997498..997971 - 474 WP_001161076.1 GrpB family protein -
K1T75_RS18330 998171..998353 - 183 WP_000923182.1 DUF645 family protein -
K1T75_RS18950 998414..998551 - 138 WP_001890145.1 hypothetical protein -
K1T75_RS18335 998745..999341 - 597 WP_000255434.1 hypothetical protein -
K1T75_RS18340 999406..999867 - 462 WP_001911578.1 lipocalin family protein -
K1T75_RS18345 1000116..1000400 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K1T75_RS18350 1000397..1000675 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K1T75_RS18355 1000826..1001239 - 414 WP_000049420.1 VOC family protein -
K1T75_RS18955 1001314..1001430 - 117 WP_086010882.1 DUF3265 domain-containing protein -
K1T75_RS18360 1001427..1001906 - 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
K1T75_RS18365 1002119..1002742 - 624 WP_000247070.1 DUF1349 domain-containing protein -
K1T75_RS18370 1002948..1003373 - 426 WP_000415750.1 hypothetical protein -
K1T75_RS18960 1003520..1003669 - 150 WP_071908333.1 DUF3265 domain-containing protein -
K1T75_RS18375 1003642..1003893 - 252 WP_001890111.1 TIGR03643 family protein -
K1T75_RS18380 1004088..1004291 - 204 WP_001911580.1 hypothetical protein -
K1T75_RS18385 1004548..1004934 - 387 WP_000703163.1 VOC family protein -
K1T75_RS18390 1005091..1005597 - 507 WP_000393074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T211918 WP_000578476.1 NZ_CP080466:1000397-1000675 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T211918 NZ_CP106849:c1110016-1109813 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT211918 WP_000381183.1 NZ_CP080466:1000116-1000400 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT211918 NZ_CP106849:c1110405-1110037 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References