58260

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 332927..333465 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ81_RS15815 Protein ID WP_000802136.1
Coordinates 332927..333226 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ81_RS15820 Protein ID WP_001107719.1
Coordinates 333223..333465 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ81_RS15755 328132..328314 + 183 WP_000923340.1 DUF645 family protein -
ASZ81_RS15760 328529..329068 + 540 WP_000099372.1 hypothetical protein -
ASZ81_RS15765 329191..329706 + 516 WP_000090011.1 hypothetical protein -
ASZ81_RS15770 329841..330377 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ81_RS15775 330846..330956 + 111 WP_071908335.1 DUF3265 domain-containing protein -
ASZ81_RS15785 331169..331321 + 153 WP_001884520.1 DUF645 family protein -
ASZ81_RS15790 331605..332048 + 444 WP_000803902.1 hypothetical protein -
ASZ81_RS15795 332052..332162 + 111 WP_071908336.1 DUF3265 domain-containing protein -
ASZ81_RS15800 332192..332470 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
ASZ81_RS15805 332467..332751 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ81_RS15815 332927..333226 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ81_RS15820 333223..333465 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ASZ81_RS15830 333884..333961 + 78 WP_071908337.1 DUF645 family protein -
ASZ81_RS20835 333965..333991 + 27 Protein_298 hypothetical protein -
ASZ81_RS20915 334577..334720 + 144 WP_001900215.1 hypothetical protein -
ASZ81_RS20415 334814..334993 + 180 Protein_300 DUF645 family protein -
ASZ81_RS15855 335211..335639 + 429 WP_000620002.1 N-acetyltransferase -
ASZ81_RS15865 336227..336709 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
ASZ81_RS15875 337517..337786 + 270 WP_001114075.1 DUF4160 domain-containing protein -
ASZ81_RS15880 337780..338301 + 522 WP_000921692.1 DUF2442 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304741..463550 158809
inside Integron - - 309821..463174 153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58260 WP_000802136.1 NZ_CP013306:c333226-332927 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58260 NZ_CP013306:c333226-332927 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58260 WP_001107719.1 NZ_CP013306:c333465-333223 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58260 NZ_CP013306:c333465-333223 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References