95380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 74626..75164 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag C4E16_RS14700 Protein ID WP_000802136.1
Coordinates 74626..74925 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag C4E16_RS14705 Protein ID WP_001107719.1
Coordinates 74922..75164 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E16_RS14650 70561..70743 + 183 WP_000923182.1 DUF645 family protein -
C4E16_RS14655 70943..71416 + 474 WP_001161076.1 GrpB family protein -
C4E16_RS14660 71431..71523 + 93 WP_014378730.1 DUF3265 domain-containing protein -
C4E16_RS14665 71565..72191 + 627 WP_000365424.1 LysE family translocator -
C4E16_RS14670 72314..73012 + 699 WP_001890502.1 hypothetical protein -
C4E16_RS14675 73022..73132 + 111 WP_079857360.1 DUF3265 domain-containing protein -
C4E16_RS14690 73710..73889 + 180 WP_001883058.1 DUF645 family protein -
C4E16_RS14695 74103..74498 + 396 WP_000870857.1 DUF3465 domain-containing protein -
C4E16_RS14700 74626..74925 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4E16_RS14705 74922..75164 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
C4E16_RS14715 75393..75971 + 579 WP_000110120.1 hypothetical protein -
C4E16_RS14720 75993..76085 + 93 WP_014164112.1 DUF3265 domain-containing protein -
C4E16_RS14730 76509..77192 + 684 WP_000877436.1 hypothetical protein -
C4E16_RS14740 77406..77672 + 267 WP_000937852.1 hypothetical protein -
C4E16_RS14750 77827..78426 + 600 WP_000429495.1 hypothetical protein -
C4E16_RS14755 78707..79642 + 936 WP_000051985.1 restriction endonuclease -
C4E16_RS14760 79608..79748 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31043..136234 105191
inside Integron - - 36123..135858 99735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T95380 WP_000802136.1 NZ_CP026648:c74925-74626 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T95380 NZ_CP026648:c74925-74626 [Vibrio cholerae O1 biovar El Tor]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT95380 WP_001107719.1 NZ_CP026648:c75164-74922 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT95380 NZ_CP026648:c75164-74922 [Vibrio cholerae O1 biovar El Tor]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References