Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 74626..75164 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag C4E16_RS14700 Protein ID WP_000802136.1
Coordinates 74626..74925 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag C4E16_RS14705 Protein ID WP_001107719.1
Coordinates 74922..75164 (-) Length 81 a.a.

Genomic Context

C4E16_RS14650C4E16_RS14655C4E16_RS14660C4E16_RS14665C4E16_RS14670C4E16_RS14675C4E16_RS14690C4E16_RS14695C4E16_RS14715C4E16_RS14720C4E16_RS14730C4E16_RS14740C4E16_RS14750C4E16_RS14755C4E16_RS14760C4E16_RS14700C4E16_RS14705
Location: 70561..70743 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 70943..71416 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 71431..71523 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 71565..72191 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 72314..73012 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 73022..73132 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 73710..73889 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 74103..74498 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 75393..75971 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 75993..76085 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 76509..77192 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 77406..77672 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 77827..78426 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 78707..79642 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 79608..79748 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 74626..74925 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 74922..75164 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS1465070561..70743+183WP_000923182.1DUF645 family protein-
C4E16_RS1465570943..71416+474WP_001161076.1GrpB family protein-
C4E16_RS1466071431..71523+93WP_014378730.1DUF3265 domain-containing protein-
C4E16_RS1466571565..72191+627WP_000365424.1LysE family translocator-
C4E16_RS1467072314..73012+699WP_001890502.1hypothetical protein-
C4E16_RS1467573022..73132+111WP_079857360.1DUF3265 domain-containing protein-
C4E16_RS1469073710..73889+180WP_001883058.1DUF645 family protein-
C4E16_RS1469574103..74498+396WP_000870857.1DUF3465 domain-containing protein-
C4E16_RS1470074626..74925-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C4E16_RS1470574922..75164-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
C4E16_RS1471575393..75971+579WP_000110120.1hypothetical protein-
C4E16_RS1472075993..76085+93WP_014164112.1DUF3265 domain-containing protein-
C4E16_RS1473076509..77192+684WP_000877436.1hypothetical protein-
C4E16_RS1474077406..77672+267WP_000937852.1hypothetical protein-
C4E16_RS1475077827..78426+600WP_000429495.1hypothetical protein-
C4E16_RS1475578707..79642+936WP_000051985.1restriction endonuclease-
C4E16_RS1476079608..79748+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T95380 WP_000802136.1 NZ_CP026648:c74925-74626 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T95380 NZ_CP026648:c74925-74626 [Vibrio cholerae O1 biovar El Tor]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT95380 WP_001107719.1 NZ_CP026648:c75164-74922 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT95380 NZ_CP026648:c75164-74922 [Vibrio cholerae O1 biovar El Tor]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References