58374

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 114298..114838 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag ASZ83_RS14545 Protein ID WP_000277238.1
Coordinates 114298..114567 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag ASZ83_RS14550 Protein ID WP_001258569.1
Coordinates 114560..114838 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ83_RS14490 109302..109544 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ83_RS14495 109788..110174 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ83_RS14500 110231..110344 + 114 WP_001900214.1 hypothetical protein -
ASZ83_RS14505 110293..110574 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ83_RS14515 110832..111368 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ83_RS14520 111505..112020 + 516 WP_001201509.1 lipocalin family protein -
ASZ83_RS14525 112170..112667 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ83_RS14530 112664..112936 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ83_RS19990 113329..113454 + 126 WP_001900195.1 DUF645 family protein -
ASZ83_RS19995 113470..113508 + 39 WP_106019118.1 hypothetical protein -
ASZ83_RS14540 113704..114150 + 447 WP_000006157.1 hypothetical protein -
ASZ83_RS14545 114298..114567 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
ASZ83_RS14550 114560..114838 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ83_RS14555 115088..115345 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ83_RS14560 115333..115635 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ83_RS14565 115924..116148 + 225 WP_001894423.1 DUF3709 domain-containing protein -
ASZ83_RS14570 116592..116711 + 120 WP_071919600.1 DUF645 family protein -
ASZ83_RS20010 116715..116768 + 54 Protein_123 DUF645 family protein -
ASZ83_RS14585 117370..118374 + 1005 WP_000964931.1 LD-carboxypeptidase -
ASZ83_RS14595 119149..119329 + 181 Protein_125 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 87981..224211 136230
inside Integron - - 93061..221594 128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T58374 WP_000277238.1 NZ_CP013316:c114567-114298 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T58374 NZ_CP013316:c114567-114298 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT58374 WP_001258569.1 NZ_CP013316:c114838-114560 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT58374 NZ_CP013316:c114838-114560 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References