Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 418494..419587 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GTF72_RS16025 Protein ID WP_000351248.1
Coordinates 419186..419587 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GTF72_RS16020 Protein ID WP_001047169.1
Coordinates 418494..419186 (+) Length 231 a.a.

Genomic Context

GTF72_RS15960GTF72_RS15965GTF72_RS15975GTF72_RS15980GTF72_RS15990GTF72_RS15995GTF72_RS16000GTF72_RS16005GTF72_RS16015GTF72_RS16020GTF72_RS16025GTF72_RS16030GTF72_RS16035GTF72_RS16040GTF72_RS16045GTF72_RS16050GTF72_RS16055GTF72_RS16070GTF72_RS16075GTF72_RS15970GTF72_RS15985GTF72_RS16010GTF72_RS16060GTF72_RS16065
Location: 413777..414154 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 414334..414555 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 414721..414834 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 414783..415010 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 415351..415683 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 415670..415984 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 416121..416555 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 416723..416878 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 418051..418323 (273 bp)
Type: Others
Protein ID: Protein_451
Location: 418494..419186 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 419186..419587 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 419557..419700 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419775..420188 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420402..420653 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420643..420930 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 421058..421513 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421835..421987 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 423186..423854 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424006..424293 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 414531..414689 (159 bp)
Type: Others
Protein ID: WP_001894455.1
Location: 415040..415198 (159 bp)
Type: Others
Protein ID: WP_001882309.1
Location: 417003..417983 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 422189..422686 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422683..422955 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF72_RS15960413777..414154+378WP_000411109.1hypothetical protein-
GTF72_RS15965414334..414555+222WP_032468461.1DUF1289 domain-containing protein-
GTF72_RS15970414531..414689-159WP_001894455.1DUF1196 family protein-
GTF72_RS15975414721..414834+114WP_001889158.1hypothetical protein-
GTF72_RS15980414783..415010+228WP_001894457.1DUF1289 domain-containing protein-
GTF72_RS15985415040..415198-159WP_001882309.1DUF1196 family protein-
GTF72_RS15990415351..415683+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF72_RS15995415670..415984+315WP_000071008.1DNA-binding transcriptional regulator-
GTF72_RS16000416121..416555+435WP_000256036.1GNAT family N-acetyltransferase-
GTF72_RS16005416723..416878+156WP_000751734.1hypothetical protein-
GTF72_RS16010417003..417983-981WP_000019370.1IS5-like element ISVch5 family transposase-
GTF72_RS16015418051..418323+273Protein_451CatB-related O-acetyltransferase-
GTF72_RS16020418494..419186+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
GTF72_RS16025419186..419587+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
GTF72_RS16030419557..419700+144WP_071908341.1DUF3265 domain-containing protein-
GTF72_RS16035419775..420188+414WP_000049417.1VOC family protein-
GTF72_RS16040420402..420653+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF72_RS16045420643..420930+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF72_RS16050421058..421513+456WP_001245327.1GNAT family N-acetyltransferase-
GTF72_RS16055421835..421987+153WP_001884520.1DUF645 family protein-
GTF72_RS16060422189..422686-498WP_000982260.1GNAT family N-acetyltransferase-
GTF72_RS16065422683..422955-273WP_000246253.1DUF1778 domain-containing protein-
GTF72_RS16070423186..423854+669WP_000043871.1hypothetical protein-
GTF72_RS16075424006..424293+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--417003..417983980
-insideGenomic islandcatB9-306905..436165129260
insideIntegron--311985..435789123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T145814 WP_000351248.1 NZ_CP047296:419186-419587 [Vibrio cholerae C6706]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T145814 NZ_CP062700:c2928933-2928778 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT145814 WP_001047169.1 NZ_CP047296:418494-419186 [Vibrio cholerae C6706]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT145814 NZ_CP062700:2928945-2929003 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References