145814

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 418494..419587 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GTF72_RS16025 Protein ID WP_000351248.1
Coordinates 419186..419587 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GTF72_RS16020 Protein ID WP_001047169.1
Coordinates 418494..419186 (+) Length 231 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF72_RS15960 413777..414154 + 378 WP_000411109.1 hypothetical protein -
GTF72_RS15965 414334..414555 + 222 WP_032468461.1 DUF1289 domain-containing protein -
GTF72_RS15970 414531..414689 - 159 WP_001894455.1 DUF1196 family protein -
GTF72_RS15975 414721..414834 + 114 WP_001889158.1 hypothetical protein -
GTF72_RS15980 414783..415010 + 228 WP_001894457.1 DUF1289 domain-containing protein -
GTF72_RS15985 415040..415198 - 159 WP_001882309.1 DUF1196 family protein -
GTF72_RS15990 415351..415683 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF72_RS15995 415670..415984 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
GTF72_RS16000 416121..416555 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
GTF72_RS16005 416723..416878 + 156 WP_000751734.1 hypothetical protein -
GTF72_RS16010 417003..417983 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GTF72_RS16015 418051..418323 + 273 Protein_451 CatB-related O-acetyltransferase -
GTF72_RS16020 418494..419186 + 693 WP_001047169.1 GNAT family N-acetyltransferase Antitoxin
GTF72_RS16025 419186..419587 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GTF72_RS16030 419557..419700 + 144 WP_071908341.1 DUF3265 domain-containing protein -
GTF72_RS16035 419775..420188 + 414 WP_000049417.1 VOC family protein -
GTF72_RS16040 420402..420653 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF72_RS16045 420643..420930 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF72_RS16050 421058..421513 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GTF72_RS16055 421835..421987 + 153 WP_001884520.1 DUF645 family protein -
GTF72_RS16060 422189..422686 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF72_RS16065 422683..422955 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF72_RS16070 423186..423854 + 669 WP_000043871.1 hypothetical protein -
GTF72_RS16075 424006..424293 + 288 WP_000426470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 417003..417983 980
- inside Genomic island catB9 - 306905..436165 129260
inside Integron - - 311985..435789 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T145814 WP_000351248.1 NZ_CP047296:419186-419587 [Vibrio cholerae C6706]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T145814 NZ_CP062700:c2928933-2928778 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT145814 WP_001047169.1 NZ_CP047296:418494-419186 [Vibrio cholerae C6706]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT145814 NZ_CP062700:2928945-2929003 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure

References