Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 328197..328963 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag N16961_RS15540 Protein ID WP_000982260.1
Coordinates 328197..328694 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag N16961_RS15545 Protein ID WP_000246253.1
Coordinates 328691..328963 (-) Length 91 a.a.

Genomic Context

N16961_RS15480N16961_RS15485N16961_RS15505N16961_RS15510N16961_RS15515N16961_RS15530N16961_RS15535N16961_RS15550N16961_RS15555N16961_RS15565N16961_RS15585N16961_RS15590N16961_RS15595N16961_RS15600N16961_RS15605N16961_RS15610N16961_RS15615N16961_RS15495N16961_RS15500N16961_RS15540N16961_RS15545N16961_RS15570N16961_RS15575
Location: 323639..324343 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 324501..324839 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 325815..326201 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 326258..326371 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 326320..326601 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 326859..327395 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 327532..328047 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 329356..329481 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 329497..329535 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 329731..330177 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 331151..331429 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 331681..331887 (207 bp)
Type: Others
Protein ID: Protein_294
Location: 332087..332188 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 332178..332564 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 332759..333010 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 332983..333132 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 333224..333466 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 324993..325310 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 325329..325571 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 328197..328694 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 328691..328963 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 330325..330594 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 330587..330865 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS15480323639..324343+705WP_000087610.1HNH endonuclease-
N16961_RS15485324501..324839+339WP_000713853.1hypothetical protein-
N16961_RS15495324993..325310-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
N16961_RS15500325329..325571-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
N16961_RS15505325815..326201+387WP_001015867.1NUDIX hydrolase-
N16961_RS15510326258..326371+114WP_001900214.1hypothetical protein-
N16961_RS15515326320..326601+282WP_001894429.1DUF1289 domain-containing protein-
N16961_RS15530326859..327395+537WP_000469482.1GNAT family N-acetyltransferase-
N16961_RS15535327532..328047+516WP_001201509.1lipocalin family protein-
N16961_RS15540328197..328694-498WP_000982260.1GNAT family N-acetyltransferaseToxin
N16961_RS15545328691..328963-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
N16961_RS15550329356..329481+126WP_001900195.1DUF645 family protein-
N16961_RS15555329497..329535+39WP_106019118.1hypothetical protein-
N16961_RS15565329731..330177+447WP_000006157.1hypothetical protein-
N16961_RS15570330325..330594-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
N16961_RS15575330587..330865-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
N16961_RS15585331151..331429+279WP_001921601.1DUF3709 domain-containing protein-
N16961_RS15590331681..331887+207Protein_294DUF3709 domain-containing protein-
N16961_RS15595332087..332188+102WP_001921603.1hypothetical protein-
N16961_RS15600332178..332564+387WP_000703163.1VOC family protein-
N16961_RS15605332759..333010+252WP_001890111.1TIGR03643 family protein-
N16961_RS15610332983..333132+150WP_071908333.1DUF3265 domain-containing protein-
N16961_RS15615333224..333466+243WP_000107461.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T104248 WP_000982260.1 NZ_CP028828:c328694-328197 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T104248 NZ_CP028828:c328694-328197 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT104248 WP_000246253.1 NZ_CP028828:c328963-328691 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT104248 NZ_CP028828:c328963-328691 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References