104248

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 328197..328963 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag N16961_RS15540 Protein ID WP_000982260.1
Coordinates 328197..328694 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag N16961_RS15545 Protein ID WP_000246253.1
Coordinates 328691..328963 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N16961_RS15480 323639..324343 + 705 WP_000087610.1 HNH endonuclease -
N16961_RS15485 324501..324839 + 339 WP_000713853.1 hypothetical protein -
N16961_RS15495 324993..325310 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
N16961_RS15500 325329..325571 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
N16961_RS15505 325815..326201 + 387 WP_001015867.1 NUDIX hydrolase -
N16961_RS15510 326258..326371 + 114 WP_001900214.1 hypothetical protein -
N16961_RS15515 326320..326601 + 282 WP_001894429.1 DUF1289 domain-containing protein -
N16961_RS15530 326859..327395 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
N16961_RS15535 327532..328047 + 516 WP_001201509.1 lipocalin family protein -
N16961_RS15540 328197..328694 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
N16961_RS15545 328691..328963 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
N16961_RS15550 329356..329481 + 126 WP_001900195.1 DUF645 family protein -
N16961_RS15555 329497..329535 + 39 WP_106019118.1 hypothetical protein -
N16961_RS15565 329731..330177 + 447 WP_000006157.1 hypothetical protein -
N16961_RS15570 330325..330594 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
N16961_RS15575 330587..330865 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
N16961_RS15585 331151..331429 + 279 WP_001921601.1 DUF3709 domain-containing protein -
N16961_RS15590 331681..331887 + 207 Protein_294 DUF3709 domain-containing protein -
N16961_RS15595 332087..332188 + 102 WP_001921603.1 hypothetical protein -
N16961_RS15600 332178..332564 + 387 WP_000703163.1 VOC family protein -
N16961_RS15605 332759..333010 + 252 WP_001890111.1 TIGR03643 family protein -
N16961_RS15610 332983..333132 + 150 WP_071908333.1 DUF3265 domain-containing protein -
N16961_RS15615 333224..333466 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306977..438073 131096
inside Integron - - 312057..437697 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T104248 WP_000982260.1 NZ_CP028828:c328694-328197 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T104248 NZ_CP028828:c328694-328197 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT104248 WP_000246253.1 NZ_CP028828:c328963-328691 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT104248 NZ_CP028828:c328963-328691 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References