Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 247143..247721 Replicon chromosome
Accession NZ_LT992493
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag DG169_RS15770 Protein ID WP_001180243.1
Coordinates 247143..247460 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag DG169_RS15775 Protein ID WP_000557292.1
Coordinates 247479..247721 (-) Length 81 a.a.

Genomic Context

DG169_RS15720DG169_RS15725DG169_RS15730DG169_RS15735DG169_RS15740DG169_RS15745DG169_RS15750DG169_RS19680DG169_RS19830DG169_RS15780DG169_RS15785DG169_RS15790DG169_RS15795DG169_RS15800DG169_RS15810DG169_RS15815DG169_RS19835DG169_RS19840DG169_RS19845DG169_RS15770DG169_RS15775
Location: 242334..242729 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 243032..243213 (182 bp)
Type: Others
Protein ID: Protein_248
Location: 243390..243785 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 243929..244465 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 244762..244941 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 245137..245562 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 245711..246058 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 246205..246498 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 246854..246949 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 247963..248472 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 248529..249182 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 249492..249710 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 250113..250346 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 250771..250951 (181 bp)
Type: Others
Protein ID: Protein_262
Location: 251218..251505 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 251516..251833 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 251830..251940 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 252117..252242 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 252258..252296 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 247143..247460 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 247479..247721 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG169_RS15720242334..242729+396WP_000046952.1hypothetical protein-
DG169_RS15725243032..243213+182Protein_248DUF645 family protein-
DG169_RS15730243390..243785+396WP_000046953.1hypothetical protein-
DG169_RS15735243929..244465+537WP_000644491.1nucleotidyltransferase family protein-
DG169_RS15740244762..244941+180WP_001883039.1DUF645 family protein-
DG169_RS15745245137..245562+426WP_000403014.1GNAT family N-acetyltransferase-
DG169_RS15750245711..246058+348WP_000933409.1hypothetical protein-
DG169_RS19680246205..246498+294WP_125460920.1hypothetical protein-
DG169_RS19830246854..246949+96WP_001907607.1DUF645 family protein-
DG169_RS15770247143..247460-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG169_RS15775247479..247721-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
DG169_RS15780247963..248472+510WP_000405987.1GNAT family N-acetyltransferase-
DG169_RS15785248529..249182+654WP_000226874.1hypothetical protein-
DG169_RS15790249492..249710+219WP_001917086.1DUF3709 domain-containing protein-
DG169_RS15795250113..250346+234WP_032482776.1DUF3709 domain-containing protein-
DG169_RS15800250771..250951+181Protein_262DUF645 family protein-
DG169_RS15810251218..251505+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
DG169_RS15815251516..251833+318WP_001232701.1HigA family addiction module antidote protein-
DG169_RS19835251830..251940+111WP_134814058.1DUF3265 domain-containing protein-
DG169_RS19840252117..252242+126WP_001944767.1DUF645 family protein-
DG169_RS19845252258..252296+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-197768..29303295264
insideIntegroncatB9-202848..29265689808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T294411 WP_001180243.1 NZ_LT992493:c247460-247143 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT294411 WP_000557292.1 NZ_LT992493:c247721-247479 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References