Detailed information of TA system TA180868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 401112..401610
• Replicon: chromosome
• Accession: NZ_CP064351
• Organism: Vibrio cholerae C6706

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK7
• Locus tag: IT766_RS15535
• Protein ID: WP_000589156.1
• Coordinates: 401112..401378 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK6
• Locus tag: IT766_RS15540
• Protein ID: WP_000643598.1
• Coordinates: 401365..401610 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT766_RS15480	396532..396738	+	207	Protein_346	DUF3709 domain-containing protein	-
IT766_RS15485	396938..397039	+	102	WP_001921603.1	hypothetical protein	-
IT766_RS15490	397029..397415	+	387	WP_000703163.1	VOC family protein	-
IT766_RS15495	397610..397861	+	252	WP_001890111.1	TIGR03643 family protein	-
IT766_RS15500	397834..397983	+	150	WP_071908333.1	DUF3265 domain-containing protein	-
IT766_RS15505	398075..398317	+	243	WP_000107461.1	hypothetical protein	-
IT766_RS15510	398569..398847	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
IT766_RS15515	399222..399365	+	144	Protein_353	DUF645 family protein	-
IT766_RS15520	399419..399457	+	39	WP_082798268.1	hypothetical protein	-
IT766_RS15525	399669..400136	+	468	WP_001289288.1	OsmC family protein	-
IT766_RS15530	400264..400927	+	664	Protein_356	hypothetical protein	-
IT766_RS15535	401112..401378	+	267	WP_000589156.1	BrnT family toxin	Toxin
IT766_RS15540	401365..401610	+	246	WP_000643598.1	hypothetical protein	Antitoxin
IT766_RS15545	401706..402500	+	795	WP_001911581.1	hypothetical protein	-
IT766_RS15550	402603..402731	+	129	WP_071908338.1	general secretion pathway protein GspI	-
IT766_RS15555	402792..402974	+	183	WP_000923182.1	DUF645 family protein	-
IT766_RS15560	403190..404194	+	1005	WP_000964920.1	LD-carboxypeptidase	-
IT766_RS15565	404347..404706	+	360	WP_001071541.1	VOC family protein	-
IT766_RS15570	404979..405212	+	234	WP_001890112.1	DUF3709 domain-containing protein	-
IT766_RS15575	405480..405986	+	507	WP_000393074.1	hypothetical protein	-
IT766_RS15580	406143..406529	+	387	WP_000703163.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	373204..502464	129260
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0	inside	Integron	-	-	378284..502088	123804

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10092.34 Da
• Isoelectric Point: 7.3171

>T180868 WP_000589156.1 NZ_CP064351:401112-401378 [Vibrio cholerae C6706]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Nucleotide

• Length: 267 bp

>T180868 NZ_CP085767:c1244921-1244580 [Enterobacter hormaechei]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGGATCTCGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAAAAATTCGGTACGGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9478.77 Da
• Isoelectric Point: 6.4832

>AT180868 WP_000643598.1 NZ_CP064351:401365-401610 [Vibrio cholerae C6706]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Nucleotide

• Length: 246 bp

>AT180868 NZ_CP085767:c1245259-1244942 [Enterobacter hormaechei]
CTGACTCACATCACATGGGGCCTGCAGCGGAATATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGGAACCGGAT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCAATGCCCACTGTGTCACCCTGTTCCAC
AACGGTTTCACCTGTGAAGCCGACACCCTTGGCAGTTGCGGTTACGTGTACATCGCCATTTATCCCACCCAGCGCTAA

Structures

Toxin

• AlphaFold DB: A0A271VMP7

Antitoxin

• AlphaFold DB: A0A271VME2