Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 575845..576478 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag ASZ87_RS17620 Protein ID WP_000843587.1
Coordinates 575845..576177 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASZ87_RS17625 Protein ID WP_000071008.1
Coordinates 576164..576478 (+) Length 105 a.a.

Genomic Context

ASZ87_RS21005ASZ87_RS20805ASZ87_RS17560ASZ87_RS21165ASZ87_RS17575ASZ87_RS17580ASZ87_RS17585ASZ87_RS21130ASZ87_RS17590ASZ87_RS17605ASZ87_RS17610ASZ87_RS17620ASZ87_RS17625ASZ87_RS17630ASZ87_RS20915ASZ87_RS17650ASZ87_RS17655ASZ87_RS17660ASZ87_RS20820ASZ87_RS17670ASZ87_RS17675ASZ87_RS17680ASZ87_RS17645
Location: 571286..571489 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 571770..571943 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 572303..572572 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 572890..573061 (172 bp)
Type: Others
Protein ID: Protein_597
Location: 573270..573656 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 573858..574100 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 574271..574648 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 574705..574819 (115 bp)
Type: Others
Protein ID: Protein_601
Location: 574768..575049 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 575215..575328 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 575277..575504 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 575845..576177 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 576164..576478 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 576615..577049 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 577217..577372 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 578545..578851 (307 bp)
Type: Others
Protein ID: Protein_610
Location: 578988..579680 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 579680..580081 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 580051..580194 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 580269..580682 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 580896..581147 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 581137..581424 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 577497..578477 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS21005571286..571489+204WP_001911745.1hypothetical protein-
ASZ87_RS20805571770..571943+174WP_001882305.1DUF3709 domain-containing protein-
ASZ87_RS17560572303..572572+270WP_001198131.1hypothetical protein-
ASZ87_RS21165572890..573061+172Protein_597DUF645 family protein-
ASZ87_RS17575573270..573656+387WP_000703163.1VOC family protein-
ASZ87_RS17580573858..574100+243WP_000107461.1hypothetical protein-
ASZ87_RS17585574271..574648+378WP_000411109.1hypothetical protein-
ASZ87_RS21130574705..574819+115Protein_601acetyltransferase-
ASZ87_RS17590574768..575049+282WP_001894453.1DUF1289 domain-containing protein-
ASZ87_RS17605575215..575328+114WP_001889158.1hypothetical protein-
ASZ87_RS17610575277..575504+228WP_001894457.1DUF1289 domain-containing protein-
ASZ87_RS17620575845..576177+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ87_RS17625576164..576478+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
ASZ87_RS17630576615..577049+435WP_000256036.1GNAT family N-acetyltransferase-
ASZ87_RS20915577217..577372+156WP_000751734.1hypothetical protein-
ASZ87_RS17645577497..578477-981WP_000019370.1IS5-like element ISVch5 family transposase-
ASZ87_RS17650578545..578851+307Protein_610CatB-related O-acetyltransferase-
ASZ87_RS17655578988..579680+693WP_001047169.1GNAT family N-acetyltransferase-
ASZ87_RS17660579680..580081+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ87_RS20820580051..580194+144WP_071908341.1DUF3265 domain-containing protein-
ASZ87_RS17670580269..580682+414WP_000049417.1VOC family protein-
ASZ87_RS17675580896..581147+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ87_RS17680581137..581424+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669
flankIS/Tn--577497..578477980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T58315 WP_000843587.1 NZ_CP013310:575845-576177 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T58315 NZ_CP013310:575845-576177 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT58315 WP_000071008.1 NZ_CP013310:576164-576478 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT58315 NZ_CP013310:576164-576478 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References