58400

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 411225..411763 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ85_RS16380 Protein ID WP_000802136.1
Coordinates 411225..411524 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ85_RS16385 Protein ID WP_001107719.1
Coordinates 411521..411763 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ85_RS16330 407160..407342 + 183 WP_000923182.1 DUF645 family protein -
ASZ85_RS16335 407542..408015 + 474 WP_001161076.1 GrpB family protein -
ASZ85_RS16340 408030..408122 + 93 WP_014378730.1 DUF3265 domain-containing protein -
ASZ85_RS16345 408164..408790 + 627 WP_000365424.1 LysE family translocator -
ASZ85_RS16350 408913..409611 + 699 WP_001890502.1 hypothetical protein -
ASZ85_RS16355 409621..409731 + 111 WP_079857360.1 DUF3265 domain-containing protein -
ASZ85_RS16370 410309..410488 + 180 WP_001883058.1 DUF645 family protein -
ASZ85_RS16375 410702..411097 + 396 WP_000870857.1 DUF3465 domain-containing protein -
ASZ85_RS16380 411225..411524 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ85_RS16385 411521..411763 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ASZ85_RS16390 411992..412570 + 579 WP_000110120.1 hypothetical protein -
ASZ85_RS16395 412592..412684 + 93 WP_014164112.1 DUF3265 domain-containing protein -
ASZ85_RS16405 413108..413791 + 684 WP_000877436.1 hypothetical protein -
ASZ85_RS16410 414005..414271 + 267 WP_000937852.1 hypothetical protein -
ASZ85_RS16415 414426..415025 + 600 WP_000429495.1 hypothetical protein -
ASZ85_RS16420 415306..416241 + 936 WP_000051985.1 restriction endonuclease -
ASZ85_RS16425 416207..416347 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 338285..496833 158548
inside Integron - - 343365..496457 153092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58400 WP_000802136.1 NZ_CP013318:c411524-411225 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58400 NZ_CP013318:c411524-411225 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58400 WP_001107719.1 NZ_CP013318:c411763-411521 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58400 NZ_CP013318:c411763-411521 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References