Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 419026..419597 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag J9265_RS16005 Protein ID WP_000351248.1
Coordinates 419196..419597 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag J9265_RS19170 Protein ID WP_001080654.1
Coordinates 419026..419196 (+) Length 57 a.a.

Genomic Context

J9265_RS15950J9265_RS15955J9265_RS15960J9265_RS15965J9265_RS15970J9265_RS15975J9265_RS15980J9265_RS15985J9265_RS15995J9265_RS19165J9265_RS19170J9265_RS16005J9265_RS16010J9265_RS16015J9265_RS16020J9265_RS16025J9265_RS16030J9265_RS19175J9265_RS16035J9265_RS19180J9265_RS19185J9265_RS16050J9265_RS16055J9265_RS15990J9265_RS16040J9265_RS16045
Location: 414221..414335 (115 bp)
Type: Others
Protein ID: Protein_462
Location: 414344..414565 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 414731..414844 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 414793..415020 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 415361..415693 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 415680..415994 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 416131..416565 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 416733..416888 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 418061..418367 (307 bp)
Type: Others
Protein ID: Protein_471
Location: 418504..418902 (399 bp)
Type: Others
Protein ID: Protein_472
Location: 419026..419196 (171 bp)
Type: Antitoxin
Protein ID: WP_001080654.1
Location: 419196..419597 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 419600..419710 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 419785..420198 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420412..420663 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420653..420940 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 421068..421523 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421580..421702 (123 bp)
Type: Others
Protein ID: Protein_480
Location: 421873..421997 (125 bp)
Type: Others
Protein ID: Protein_481
Location: 422114..422182 (69 bp)
Type: Others
Protein ID: Protein_482
Location: 423117..423179 (63 bp)
Type: Others
Protein ID: Protein_485
Location: 423196..423864 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424016..424303 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 417013..417993 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 422199..422696 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422693..422965 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J9265_RS15950 (J9265_15950)414221..414335+115Protein_462acetyltransferase-
J9265_RS15955 (J9265_15955)414344..414565+222WP_032468461.1DUF1289 domain-containing protein-
J9265_RS15960 (J9265_15960)414731..414844+114WP_001889158.1hypothetical protein-
J9265_RS15965 (J9265_15965)414793..415020+228WP_001894457.1DUF1289 domain-containing protein-
J9265_RS15970 (J9265_15970)415361..415693+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
J9265_RS15975 (J9265_15975)415680..415994+315WP_000071008.1DNA-binding transcriptional regulator-
J9265_RS15980 (J9265_15980)416131..416565+435WP_000256036.1GNAT family N-acetyltransferase-
J9265_RS15985 (J9265_15985)416733..416888+156WP_000751734.1hypothetical protein-
J9265_RS15990 (J9265_15990)417013..417993-981WP_000019370.1IS5-like element ISVch5 family transposase-
J9265_RS15995 (J9265_15995)418061..418367+307Protein_471CatB-related O-acetyltransferase-
J9265_RS19165418504..418902+399Protein_472GNAT family N-acetyltransferase-
J9265_RS19170419026..419196+171WP_001080654.1hypothetical proteinAntitoxin
J9265_RS16005 (J9265_16005)419196..419597+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
J9265_RS16010 (J9265_16010)419600..419710+111WP_082798255.1DUF3265 domain-containing protein-
J9265_RS16015 (J9265_16015)419785..420198+414WP_000049417.1VOC family protein-
J9265_RS16020 (J9265_16020)420412..420663+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
J9265_RS16025 (J9265_16025)420653..420940+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
J9265_RS16030 (J9265_16030)421068..421523+456WP_001245327.1GNAT family N-acetyltransferase-
J9265_RS19175421580..421702+123Protein_480acetyltransferase-
J9265_RS16035 (J9265_16035)421873..421997+125Protein_481DUF645 family protein-
J9265_RS19180422114..422182+69Protein_482acetyltransferase-
J9265_RS16040 (J9265_16040)422199..422696-498WP_000982260.1GNAT family N-acetyltransferase-
J9265_RS16045 (J9265_16045)422693..422965-273WP_000246253.1DUF1778 domain-containing protein-
J9265_RS19185423117..423179+63Protein_485acetyltransferase-
J9265_RS16050 (J9265_16050)423196..423864+669WP_000043871.1hypothetical protein-
J9265_RS16055 (J9265_16055)424016..424303+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805
flankIS/Tn--417013..417993980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T198988 WP_000351248.1 NZ_CP072848:419196-419597 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T198988 NZ_CP097080:c194047-193565 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT198988 WP_001080654.1 NZ_CP072848:419026-419196 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT198988 NZ_CP097080:c194301-194035 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SJJ1

References