198988

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 419026..419597 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag J9265_RS16005 Protein ID WP_000351248.1
Coordinates 419196..419597 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag J9265_RS19170 Protein ID WP_001080654.1
Coordinates 419026..419196 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS15950 (J9265_15950) 414221..414335 + 115 Protein_462 acetyltransferase -
J9265_RS15955 (J9265_15955) 414344..414565 + 222 WP_032468461.1 DUF1289 domain-containing protein -
J9265_RS15960 (J9265_15960) 414731..414844 + 114 WP_001889158.1 hypothetical protein -
J9265_RS15965 (J9265_15965) 414793..415020 + 228 WP_001894457.1 DUF1289 domain-containing protein -
J9265_RS15970 (J9265_15970) 415361..415693 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
J9265_RS15975 (J9265_15975) 415680..415994 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
J9265_RS15980 (J9265_15980) 416131..416565 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
J9265_RS15985 (J9265_15985) 416733..416888 + 156 WP_000751734.1 hypothetical protein -
J9265_RS15990 (J9265_15990) 417013..417993 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
J9265_RS15995 (J9265_15995) 418061..418367 + 307 Protein_471 CatB-related O-acetyltransferase -
J9265_RS19165 418504..418902 + 399 Protein_472 GNAT family N-acetyltransferase -
J9265_RS19170 419026..419196 + 171 WP_001080654.1 hypothetical protein Antitoxin
J9265_RS16005 (J9265_16005) 419196..419597 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
J9265_RS16010 (J9265_16010) 419600..419710 + 111 WP_082798255.1 DUF3265 domain-containing protein -
J9265_RS16015 (J9265_16015) 419785..420198 + 414 WP_000049417.1 VOC family protein -
J9265_RS16020 (J9265_16020) 420412..420663 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J9265_RS16025 (J9265_16025) 420653..420940 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
J9265_RS16030 (J9265_16030) 421068..421523 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
J9265_RS19175 421580..421702 + 123 Protein_480 acetyltransferase -
J9265_RS16035 (J9265_16035) 421873..421997 + 125 Protein_481 DUF645 family protein -
J9265_RS19180 422114..422182 + 69 Protein_482 acetyltransferase -
J9265_RS16040 (J9265_16040) 422199..422696 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
J9265_RS16045 (J9265_16045) 422693..422965 - 273 WP_000246253.1 DUF1778 domain-containing protein -
J9265_RS19185 423117..423179 + 63 Protein_485 acetyltransferase -
J9265_RS16050 (J9265_16050) 423196..423864 + 669 WP_000043871.1 hypothetical protein -
J9265_RS16055 (J9265_16055) 424016..424303 + 288 WP_000426470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805
flank IS/Tn - - 417013..417993 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T198988 WP_000351248.1 NZ_CP072848:419196-419597 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T198988 NZ_CP097080:c194047-193565 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT198988 WP_001080654.1 NZ_CP072848:419026-419196 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT198988 NZ_CP097080:c194301-194035 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References