198994

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 433447..434006 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag J9265_RS16145 Protein ID WP_000578476.1
Coordinates 433447..433725 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag J9265_RS16150 Protein ID WP_000381183.1
Coordinates 433722..434006 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS16100 (J9265_16100) 428747..429184 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
J9265_RS16105 (J9265_16105) 429245..429466 + 222 Protein_498 GNAT family N-acetyltransferase -
J9265_RS16110 (J9265_16110) 429641..430513 + 873 WP_000254716.1 DUF3800 domain-containing protein -
J9265_RS16115 (J9265_16115) 430663..431262 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
J9265_RS16120 (J9265_16120) 431319..431387 + 69 Protein_501 acetyltransferase -
J9265_RS16125 (J9265_16125) 431454..431723 + 270 WP_001114075.1 DUF4160 domain-containing protein -
J9265_RS16130 (J9265_16130) 431717..432238 + 522 WP_000921691.1 DUF2442 domain-containing protein -
J9265_RS16135 (J9265_16135) 432537..432662 + 126 WP_001905700.1 DUF645 family protein -
J9265_RS16140 (J9265_16140) 432913..433308 + 396 WP_001000867.1 hypothetical protein -
J9265_RS16145 (J9265_16145) 433447..433725 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
J9265_RS16150 (J9265_16150) 433722..434006 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J9265_RS16155 (J9265_16155) 434200..434715 + 516 WP_000343779.1 GNAT family protein -
J9265_RS16160 (J9265_16160) 434899..435312 + 414 WP_000049420.1 VOC family protein -
J9265_RS16165 (J9265_16165) 435867..437044 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805
flank IS/Tn - - 428747..429184 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T198994 WP_000578476.1 NZ_CP072848:c433725-433447 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T198994 NZ_CP097082:3957609-3957827 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT198994 WP_000381183.1 NZ_CP072848:c434006-433722 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT198994 NZ_CP097082:3957208-3957582 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References