Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 392053..392600 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag KAF59_RS15880 Protein ID WP_000229317.1
Coordinates 392298..392600 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag KAF59_RS15875 Protein ID WP_000861987.1
Coordinates 392053..392310 (+) Length 86 a.a.

Genomic Context

KAF59_RS15830KAF59_RS18910KAF59_RS15835KAF59_RS18915KAF59_RS18920KAF59_RS15850KAF59_RS15855KAF59_RS15860KAF59_RS18925KAF59_RS15870KAF59_RS18930KAF59_RS15875KAF59_RS15880KAF59_RS15885KAF59_RS15890KAF59_RS15895KAF59_RS15900KAF59_RS15905KAF59_RS15910KAF59_RS15915KAF59_RS15920KAF59_RS15840KAF59_RS15845
Location: 387082..387537 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 387594..387716 (123 bp)
Type: Others
Protein ID: Protein_413
Location: 387887..388011 (125 bp)
Type: Others
Protein ID: Protein_414
Location: 388128..388196 (69 bp)
Type: Others
Protein ID: Protein_415
Location: 389131..389193 (63 bp)
Type: Others
Protein ID: Protein_418
Location: 389210..389878 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 390030..390317 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 390458..390829 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 391052..391321 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 391318..391851 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 391861..391971 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 392053..392310 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 392298..392600 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 392834..393751 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 393908..394297 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 394433..394642 (210 bp)
Type: Others
Protein ID: Protein_429
Location: 394761..395198 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 395259..395480 (222 bp)
Type: Others
Protein ID: Protein_431
Location: 395655..396527 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 396677..397276 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 397333..397401 (69 bp)
Type: Others
Protein ID: Protein_434
Location: 388213..388710 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 388707..388979 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KAF59_RS15830 (KAF59_15830)387082..387537+456WP_001245327.1GNAT family N-acetyltransferase-
KAF59_RS18910387594..387716+123Protein_413acetyltransferase-
KAF59_RS15835 (KAF59_15835)387887..388011+125Protein_414DUF645 family protein-
KAF59_RS18915388128..388196+69Protein_415acetyltransferase-
KAF59_RS15840 (KAF59_15840)388213..388710-498WP_000982260.1GNAT family N-acetyltransferase-
KAF59_RS15845 (KAF59_15845)388707..388979-273WP_000246253.1DUF1778 domain-containing protein-
KAF59_RS18920389131..389193+63Protein_418acetyltransferase-
KAF59_RS15850 (KAF59_15850)389210..389878+669WP_000043871.1hypothetical protein-
KAF59_RS15855 (KAF59_15855)390030..390317+288WP_000426470.1hypothetical protein-
KAF59_RS15860 (KAF59_15860)390458..390829+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
KAF59_RS18925391052..391321+270WP_000179600.1DUF1778 domain-containing protein-
KAF59_RS15870 (KAF59_15870)391318..391851+534WP_000118351.1GNAT family N-acetyltransferase-
KAF59_RS18930391861..391971+111WP_086010065.1DUF3265 domain-containing protein-
KAF59_RS15875 (KAF59_15875)392053..392310+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
KAF59_RS15880 (KAF59_15880)392298..392600+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KAF59_RS15885 (KAF59_15885)392834..393751+918WP_000186333.1alpha/beta hydrolase-
KAF59_RS15890 (KAF59_15890)393908..394297+390WP_001081302.1hypothetical protein-
KAF59_RS15895 (KAF59_15895)394433..394642+210Protein_429GNAT family N-acetyltransferase-
KAF59_RS15900 (KAF59_15900)394761..395198+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
KAF59_RS15905 (KAF59_15905)395259..395480+222Protein_431GNAT family N-acetyltransferase-
KAF59_RS15910 (KAF59_15910)395655..396527+873WP_000254716.1DUF3800 domain-containing protein-
KAF59_RS15915 (KAF59_15915)396677..397276+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
KAF59_RS15920 (KAF59_15920)397333..397401+69Protein_434acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306928..40218995261
insideIntegroncatB9-312008..40181389805
flankIS/Tn--394761..395198437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T199011 WP_000229317.1 NZ_CP072850:392298-392600 [Vibrio cholerae MO10]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T199011 NZ_CP097103:334263-334565 [Pseudomonas sp. NY11382]
ATGACAAACATCAAACTGACCAAATGGGACGCTGTGGACCATTTGAAAACTGAAGAGGACATGGCCTTGTACCTTGAGGC
CTGTCTGGAGGAAAACGACCCTGCACTGCTCGCTGCTGCCTTGGGTGATATCGCTCGCGCTCGTGGTATGGCTCAGTTGG
CACGTGATACTGGGCTCACGCGGGAAGGGTTGTACAAGGCCTTGTCTGCTGAAGGTAATCCGAGCCTGGCGACCATCATG
AAGGTAATGGCGGCGCTTGGCGTTCGGCTCCATGCCGAAGTGCTGCCACGCTCAGTGGGGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT199011 WP_000861987.1 NZ_CP072850:392053-392310 [Vibrio cholerae MO10]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT199011 NZ_CP097103:334011-334253 [Pseudomonas sp. NY11382]
CTGCGGGATCCGCGGGCGAAAGCTCGCATAAACGCCCGGTTGCGGCGGTTGGAGCTCGGAGTGAAGGGTGACTGTAAGCC
AGTTGCTGAGGGGGTGTCCGAGCTTCGGGTCGATTATGGTCCGGGCTATCGGGTGTATTTCGTTCAGCGAGGTTATGAAG
TGATCATCCTTCTGGCAGGTGGCGACAAATCTAGCCAAGCCAGGGATATCAAATCTGCGCTCAAGCTGGCTCGTGACCTC
TAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References