Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343155..343714 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GQX72_RS15405 Protein ID WP_000578476.1
Coordinates 343155..343433 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GQX72_RS15410 Protein ID WP_000381183.1
Coordinates 343430..343714 (-) Length 95 a.a.

Genomic Context

GQX72_RS15355GQX72_RS15360GQX72_RS15365GQX72_RS15370GQX72_RS15375GQX72_RS15380GQX72_RS15385GQX72_RS15390GQX72_RS15395GQX72_RS15415GQX72_RS15420GQX72_RS15425GQX72_RS15430GQX72_RS15435GQX72_RS15440GQX72_RS15445GQX72_RS15450GQX72_RS15405GQX72_RS15410
Location: 338233..338739 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 338896..339282 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 339539..339742 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 339937..340188 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 340161..340310 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 340457..340882 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 341088..341711 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 341924..342403 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 342591..343004 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 343909..344424 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 344489..345085 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 345477..345659 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 345859..346332 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 346347..346439 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 346481..347107 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 347230..347928 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 347938..348048 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 343155..343433 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 343430..343714 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQX72_RS15355338233..338739+507WP_000393074.1hypothetical protein-
GQX72_RS15360338896..339282+387WP_000703163.1VOC family protein-
GQX72_RS15365339539..339742+204WP_001911580.1hypothetical protein-
GQX72_RS15370339937..340188+252WP_001890111.1TIGR03643 family protein-
GQX72_RS15375340161..340310+150WP_071908333.1DUF3265 domain-containing protein-
GQX72_RS15380340457..340882+426WP_000415750.1hypothetical protein-
GQX72_RS15385341088..341711+624WP_000247070.1DUF1349 domain-containing protein-
GQX72_RS15390341924..342403+480WP_000009888.1lecithin retinol acyltransferase family protein-
GQX72_RS15395342591..343004+414WP_000049420.1VOC family protein-
GQX72_RS15405343155..343433-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
GQX72_RS15410343430..343714-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GQX72_RS15415343909..344424+516WP_001201520.1lipocalin family protein-
GQX72_RS15420344489..345085+597WP_000255434.1hypothetical protein-
GQX72_RS15425345477..345659+183WP_000923182.1DUF645 family protein-
GQX72_RS15430345859..346332+474WP_001161076.1GrpB family protein-
GQX72_RS15435346347..346439+93WP_014378730.1DUF3265 domain-containing protein-
GQX72_RS15440346481..347107+627WP_000365424.1LysE family translocator-
GQX72_RS15445347230..347928+699WP_001890502.1hypothetical protein-
GQX72_RS15450347938..348048+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305960..411159105199
insideIntegron--311040..41078399743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145396 WP_000578476.1 NZ_CP047060:c343433-343155 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145396 NZ_CP062372:c2041573-2041364 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145396 WP_000381183.1 NZ_CP047060:c343714-343430 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145396 NZ_CP062372:c2041878-2041585 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References