145396

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343155..343714 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GQX72_RS15405 Protein ID WP_000578476.1
Coordinates 343155..343433 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GQX72_RS15410 Protein ID WP_000381183.1
Coordinates 343430..343714 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS15355 338233..338739 + 507 WP_000393074.1 hypothetical protein -
GQX72_RS15360 338896..339282 + 387 WP_000703163.1 VOC family protein -
GQX72_RS15365 339539..339742 + 204 WP_001911580.1 hypothetical protein -
GQX72_RS15370 339937..340188 + 252 WP_001890111.1 TIGR03643 family protein -
GQX72_RS15375 340161..340310 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GQX72_RS15380 340457..340882 + 426 WP_000415750.1 hypothetical protein -
GQX72_RS15385 341088..341711 + 624 WP_000247070.1 DUF1349 domain-containing protein -
GQX72_RS15390 341924..342403 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
GQX72_RS15395 342591..343004 + 414 WP_000049420.1 VOC family protein -
GQX72_RS15405 343155..343433 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GQX72_RS15410 343430..343714 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GQX72_RS15415 343909..344424 + 516 WP_001201520.1 lipocalin family protein -
GQX72_RS15420 344489..345085 + 597 WP_000255434.1 hypothetical protein -
GQX72_RS15425 345477..345659 + 183 WP_000923182.1 DUF645 family protein -
GQX72_RS15430 345859..346332 + 474 WP_001161076.1 GrpB family protein -
GQX72_RS15435 346347..346439 + 93 WP_014378730.1 DUF3265 domain-containing protein -
GQX72_RS15440 346481..347107 + 627 WP_000365424.1 LysE family translocator -
GQX72_RS15445 347230..347928 + 699 WP_001890502.1 hypothetical protein -
GQX72_RS15450 347938..348048 + 111 WP_079857360.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145396 WP_000578476.1 NZ_CP047060:c343433-343155 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145396 NZ_CP062372:c2041573-2041364 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145396 WP_000381183.1 NZ_CP047060:c343714-343430 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145396 NZ_CP062372:c2041878-2041585 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References