113810

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 211345..212111 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag EEL44_RS01475 Protein ID WP_000982260.1
Coordinates 211614..212111 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag EEL44_RS01470 Protein ID WP_000246253.1
Coordinates 211345..211617 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS01400 206842..207084 - 243 WP_000107461.1 hypothetical protein -
EEL44_RS01405 207176..207325 - 150 WP_071908333.1 DUF3265 domain-containing protein -
EEL44_RS01410 207298..207549 - 252 WP_001890111.1 TIGR03643 family protein -
EEL44_RS01415 207744..208130 - 387 WP_000703163.1 VOC family protein -
EEL44_RS01420 208120..208221 - 102 WP_001921603.1 hypothetical protein -
EEL44_RS01425 208421..208627 - 207 Protein_252 DUF3709 domain-containing protein -
EEL44_RS01430 208879..209157 - 279 WP_001921601.1 DUF3709 domain-containing protein -
EEL44_RS01440 209443..209721 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
EEL44_RS01445 209714..209983 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
EEL44_RS01450 210131..210577 - 447 WP_000006157.1 hypothetical protein -
EEL44_RS01460 210773..210811 - 39 WP_106019118.1 hypothetical protein -
EEL44_RS01465 210827..210952 - 126 WP_001900195.1 DUF645 family protein -
EEL44_RS01470 211345..211617 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
EEL44_RS01475 211614..212111 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
EEL44_RS01480 212261..212776 - 516 WP_001201509.1 lipocalin family protein -
EEL44_RS01485 212913..213449 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
EEL44_RS01500 213707..213988 - 282 WP_001894429.1 DUF1289 domain-containing protein -
EEL44_RS01505 213937..214050 - 114 WP_001900214.1 hypothetical protein -
EEL44_RS01510 214107..214493 - 387 WP_001015867.1 NUDIX hydrolase -
EEL44_RS01515 214737..214979 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EEL44_RS01520 214998..215315 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
EEL44_RS01530 215469..215807 - 339 WP_000713853.1 hypothetical protein -
EEL44_RS01535 215965..216669 - 705 WP_000087610.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 126763..233717 106954
inside Integron - - 127139..226875 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T113810 WP_000982260.1 NZ_CP033513:211614-212111 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T113810 NZ_CP033513:211614-212111 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT113810 WP_000246253.1 NZ_CP033513:211345-211617 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT113810 NZ_CP033513:211345-211617 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References