180874

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 481650..482283 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag IT766_RS16220 Protein ID WP_000843587.1
Coordinates 481650..481982 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IT766_RS16225 Protein ID WP_000071008.1
Coordinates 481969..482283 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS16165 477091..477294 + 204 WP_001911745.1 hypothetical protein -
IT766_RS16170 477575..477748 + 174 WP_001882305.1 DUF3709 domain-containing protein -
IT766_RS16175 478108..478377 + 270 WP_001198131.1 hypothetical protein -
IT766_RS16180 478695..478866 + 172 Protein_486 DUF645 family protein -
IT766_RS16185 479075..479461 + 387 WP_000703163.1 VOC family protein -
IT766_RS16190 479663..479905 + 243 WP_000107461.1 hypothetical protein -
IT766_RS16195 480076..480453 + 378 WP_000411109.1 hypothetical protein -
IT766_RS16200 480510..480624 + 115 Protein_490 acetyltransferase -
IT766_RS16205 480573..480854 + 282 WP_001894453.1 DUF1289 domain-containing protein -
IT766_RS16210 481020..481133 + 114 WP_001889158.1 hypothetical protein -
IT766_RS16215 481082..481309 + 228 WP_001894457.1 DUF1289 domain-containing protein -
IT766_RS16220 481650..481982 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IT766_RS16225 481969..482283 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
IT766_RS16230 482420..482854 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
IT766_RS16235 483022..483177 + 156 WP_000751734.1 hypothetical protein -
IT766_RS16240 483302..484282 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
IT766_RS16245 484350..484622 + 273 Protein_499 CatB-related O-acetyltransferase -
IT766_RS16250 484793..485485 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
IT766_RS16255 485485..485886 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
IT766_RS16260 485856..485999 + 144 WP_071908341.1 DUF3265 domain-containing protein -
IT766_RS16265 486074..486487 + 414 WP_000049417.1 VOC family protein -
IT766_RS16270 486701..486952 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IT766_RS16275 486942..487229 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804
flank IS/Tn - - 483302..484282 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T180874 WP_000843587.1 NZ_CP064351:481650-481982 [Vibrio cholerae C6706]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T180874 NZ_CP085767:c2310435-2310148 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAAACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT180874 WP_000071008.1 NZ_CP064351:481969-482283 [Vibrio cholerae C6706]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT180874 NZ_CP085767:c2310744-2310442 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References