58395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 377453..377993 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag ASZ85_RS16010 Protein ID WP_000277238.1
Coordinates 377453..377722 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag ASZ85_RS16015 Protein ID WP_001258569.1
Coordinates 377715..377993 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ85_RS15955 372457..372699 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ85_RS15960 372943..373329 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ85_RS15965 373386..373499 + 114 WP_001900214.1 hypothetical protein -
ASZ85_RS15970 373448..373729 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ85_RS15980 373987..374523 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ85_RS15985 374660..375175 + 516 WP_001201509.1 lipocalin family protein -
ASZ85_RS15990 375325..375822 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ85_RS15995 375819..376091 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ85_RS20980 376484..376609 + 126 WP_001900195.1 DUF645 family protein -
ASZ85_RS20985 376625..376663 + 39 WP_106019118.1 hypothetical protein -
ASZ85_RS16005 376859..377305 + 447 WP_000006157.1 hypothetical protein -
ASZ85_RS16010 377453..377722 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
ASZ85_RS16015 377715..377993 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ85_RS16020 378243..378500 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ85_RS16025 378488..378790 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ85_RS16030 379079..379303 + 225 WP_001894423.1 DUF3709 domain-containing protein -
ASZ85_RS16035 379747..379866 + 120 WP_071919600.1 DUF645 family protein -
ASZ85_RS21000 379870..379923 + 54 Protein_360 DUF645 family protein -
ASZ85_RS16050 380525..381529 + 1005 WP_000964931.1 LD-carboxypeptidase -
ASZ85_RS16060 382304..382484 + 181 Protein_362 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 338285..496833 158548
inside Integron - - 343365..496457 153092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T58395 WP_000277238.1 NZ_CP013318:c377722-377453 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T58395 NZ_CP013318:c377722-377453 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT58395 WP_001258569.1 NZ_CP013318:c377993-377715 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT58395 NZ_CP013318:c377993-377715 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References