Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 416273..417366 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag CSW01_RS16695 Protein ID WP_000351248.1
Coordinates 416965..417366 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CSW01_RS16690 Protein ID WP_001047169.1
Coordinates 416273..416965 (+) Length 231 a.a.

Genomic Context

CSW01_RS16620CSW01_RS19995CSW01_RS16625CSW01_RS16640CSW01_RS16645CSW01_RS16660CSW01_RS16665CSW01_RS16675CSW01_RS19850CSW01_RS16685CSW01_RS16690CSW01_RS16695CSW01_RS16700CSW01_RS16705CSW01_RS16710CSW01_RS16715CSW01_RS16720CSW01_RS16725CSW01_RS16750CSW01_RS16755CSW01_RS16680CSW01_RS16735CSW01_RS16740
Location: 411556..411933 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 411990..412104 (115 bp)
Type: Others
Protein ID: Protein_434
Location: 412053..412334 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 412500..412613 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 412562..412789 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 413130..413462 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 413449..413763 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 413900..414334 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 414502..414657 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 415830..416136 (307 bp)
Type: Others
Protein ID: Protein_443
Location: 416273..416965 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 416965..417366 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 417336..417479 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 417554..417967 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 418181..418432 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 418422..418709 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 418837..419292 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 419614..419766 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 420965..421633 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421785..422072 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 414782..415762 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 419968..420465 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 420462..420734 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS16620411556..411933+378WP_000411109.1hypothetical protein-
CSW01_RS19995411990..412104+115Protein_434acetyltransferase-
CSW01_RS16625412053..412334+282WP_001894453.1DUF1289 domain-containing protein-
CSW01_RS16640412500..412613+114WP_001889158.1hypothetical protein-
CSW01_RS16645412562..412789+228WP_001894457.1DUF1289 domain-containing protein-
CSW01_RS16660413130..413462+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
CSW01_RS16665413449..413763+315WP_000071008.1DNA-binding transcriptional regulator-
CSW01_RS16675413900..414334+435WP_000256036.1GNAT family N-acetyltransferase-
CSW01_RS19850414502..414657+156WP_000751734.1hypothetical protein-
CSW01_RS16680414782..415762-981WP_000019370.1IS5-like element ISVch5 family transposase-
CSW01_RS16685415830..416136+307Protein_443CatB-related O-acetyltransferase-
CSW01_RS16690416273..416965+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
CSW01_RS16695416965..417366+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
CSW01_RS16700417336..417479+144WP_071908341.1DUF3265 domain-containing protein-
CSW01_RS16705417554..417967+414WP_000049417.1VOC family protein-
CSW01_RS16710418181..418432+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
CSW01_RS16715418422..418709+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
CSW01_RS16720418837..419292+456WP_001245327.1GNAT family N-acetyltransferase-
CSW01_RS16725419614..419766+153WP_001884520.1DUF645 family protein-
CSW01_RS16735419968..420465-498WP_000982260.1GNAT family N-acetyltransferase-
CSW01_RS16740420462..420734-273WP_000246253.1DUF1778 domain-containing protein-
CSW01_RS16750420965..421633+669WP_000043871.1hypothetical protein-
CSW01_RS16755421785..422072+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262
flankIS/Tn--414782..415762980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T87026 WP_000351248.1 NZ_CP024163:416965-417366 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T87026 NZ_CP024163:416965-417366 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT87026 WP_001047169.1 NZ_CP024163:416273-416965 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT87026 NZ_CP024163:416273-416965 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References