145829

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365749..366327 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF73_RS15580 Protein ID WP_001180243.1
Coordinates 365749..366066 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF73_RS15585 Protein ID WP_000557292.1
Coordinates 366085..366327 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS15535 360979..361335 + 357 WP_001094969.1 hypothetical protein -
GTF73_RS15540 361638..361819 + 182 Protein_351 DUF645 family protein -
GTF73_RS15545 361996..362391 + 396 WP_000046953.1 hypothetical protein -
GTF73_RS15550 362535..363071 + 537 WP_000644491.1 nucleotidyltransferase family protein -
GTF73_RS15555 363368..363547 + 180 WP_001883039.1 DUF645 family protein -
GTF73_RS15560 363743..364168 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
GTF73_RS15565 364317..364664 + 348 WP_000933409.1 hypothetical protein -
GTF73_RS15570 364811..365104 + 294 WP_125460920.1 hypothetical protein -
GTF73_RS15575 365460..365555 + 96 WP_001907607.1 DUF645 family protein -
GTF73_RS15580 365749..366066 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF73_RS15585 366085..366327 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF73_RS15590 366569..367078 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
GTF73_RS15595 367135..367788 + 654 WP_000226874.1 hypothetical protein -
GTF73_RS15600 368098..368316 + 219 WP_001917086.1 DUF3709 domain-containing protein -
GTF73_RS15605 368719..368952 + 234 WP_032482776.1 DUF3709 domain-containing protein -
GTF73_RS15610 369377..369557 + 181 Protein_365 DUF645 family protein -
GTF73_RS15615 369824..370111 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF73_RS15620 370122..370439 + 318 WP_001232701.1 HigA family addiction module antidote protein -
GTF73_RS15625 370436..370546 + 111 WP_134814058.1 DUF3265 domain-containing protein -
GTF73_RS15630 370723..370848 + 126 WP_001944767.1 DUF645 family protein -
GTF73_RS15635 370864..370902 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145829 WP_001180243.1 NZ_CP047298:c366066-365749 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145829 NZ_CP062701:49073-49378 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145829 WP_000557292.1 NZ_CP047298:c366327-366085 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145829 NZ_CP062701:48853-49071 [Escherichia coli O157:H7]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References