Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 972984..973388 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag FDZ90_RS19335 Protein ID WP_001114075.1
Coordinates 973119..973388 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag FDZ90_RS19330 Protein ID WP_099607150.1
Coordinates 972984..973088 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ90_RS19295 968486..969403 + 918 WP_000186333.1 alpha/beta hydrolase -
FDZ90_RS19300 969560..969949 + 390 WP_001081302.1 hypothetical protein -
FDZ90_RS19305 970085..970294 + 210 Protein_914 GNAT family N-acetyltransferase -
FDZ90_RS19310 970413..970850 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
FDZ90_RS19315 970913..971131 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
FDZ90_RS19320 971306..972178 + 873 WP_000254716.1 DUF3800 domain-containing protein -
FDZ90_RS19325 972328..972927 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
FDZ90_RS19330 972984..973088 + 105 WP_099607150.1 acetyltransferase Antitoxin
FDZ90_RS19335 973119..973388 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
FDZ90_RS19340 973382..973903 + 522 WP_000921691.1 DUF2442 domain-containing protein -
FDZ90_RS19345 974202..974327 + 126 WP_001905700.1 DUF645 family protein -
FDZ90_RS19350 974578..974973 + 396 WP_001000867.1 hypothetical protein -
FDZ90_RS19355 975112..975390 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
FDZ90_RS19360 975387..975671 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
FDZ90_RS19365 975865..976380 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
FDZ90_RS19370 976564..976977 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 882589..977840 95251
inside Integron catB9 - 887669..977464 89795
flank IS/Tn - - 970413..970850 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T125050 WP_001114075.1 NZ_CP040173:973119-973388 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T125050 NZ_CP040173:973119-973388 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT125050 WP_099607150.1 NZ_CP040173:972984-973088 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT125050 NZ_CP040173:972984-973088 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References