254481

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 817629..818188 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag NW313_RS17990 Protein ID WP_000578476.1
Coordinates 817629..817907 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag NW313_RS17995 Protein ID WP_000381183.1
Coordinates 817904..818188 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW313_RS17945 812929..813366 + 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
NW313_RS17950 813427..813648 + 222 Protein_813 GNAT family N-acetyltransferase -
NW313_RS17955 813823..814695 + 873 WP_000254716.1 DUF3800 domain-containing protein -
NW313_RS17960 814845..815444 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
NW313_RS17965 815501..815569 + 69 Protein_816 acetyltransferase -
NW313_RS17970 815636..815905 + 270 WP_001114075.1 DUF4160 domain-containing protein -
NW313_RS17975 815899..816420 + 522 WP_000921691.1 DUF2442 domain-containing protein -
NW313_RS17980 816719..816844 + 126 WP_001905700.1 DUF645 family protein -
NW313_RS17985 817095..817490 + 396 WP_001000867.1 hypothetical protein -
NW313_RS17990 817629..817907 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
NW313_RS17995 817904..818188 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NW313_RS18000 818382..818897 + 516 WP_000343779.1 GNAT family protein -
NW313_RS18005 819081..819494 + 414 WP_000049420.1 VOC family protein -
NW313_RS18010 820049..821226 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 713852..820357 106505
inside Integron catB9 - 718932..819981 101049
flank IS/Tn - - 812929..813366 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T254481 WP_000578476.1 NZ_CP102928:c817907-817629 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT254481 WP_000381183.1 NZ_CP102928:c818188-817904 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References