23791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1017920..1018479 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VCD_RS19360 Protein ID WP_000578476.1
Coordinates 1018201..1018479 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VCD_RS19355 Protein ID WP_000381183.1
Coordinates 1017920..1018204 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS20490 1013586..1013696 - 111 WP_079857360.1 DUF3265 domain-containing protein -
VCD_RS19325 1013706..1014404 - 699 WP_001890502.1 hypothetical protein -
VCD_RS19330 1014527..1015153 - 627 WP_000365424.1 LysE family translocator -
VCD_RS20495 1015195..1015287 - 93 WP_014378730.1 DUF3265 domain-containing protein -
VCD_RS19335 1015302..1015775 - 474 WP_001161076.1 GrpB family protein -
VCD_RS19340 1015975..1016157 - 183 WP_000923182.1 DUF645 family protein -
VCD_RS19345 1016549..1017145 - 597 WP_000255434.1 hypothetical protein -
VCD_RS19350 1017210..1017725 - 516 WP_001201520.1 lipocalin family protein -
VCD_RS19355 1017920..1018204 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VCD_RS19360 1018201..1018479 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
VCD_RS19365 1018630..1019043 - 414 WP_000049420.1 VOC family protein -
VCD_RS19370 1019231..1019710 - 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
VCD_RS19375 1019923..1020546 - 624 WP_000247070.1 DUF1349 domain-containing protein -
VCD_RS19380 1020752..1021177 - 426 WP_000415750.1 hypothetical protein -
VCD_RS20510 1021324..1021473 - 150 WP_071908333.1 DUF3265 domain-containing protein -
VCD_RS19385 1021446..1021697 - 252 WP_001890111.1 TIGR03643 family protein -
VCD_RS19390 1021892..1022095 - 204 WP_001911580.1 hypothetical protein -
VCD_RS19395 1022352..1022738 - 387 WP_000703163.1 VOC family protein -
VCD_RS19400 1022895..1023401 - 507 WP_000393074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T23791 WP_000578476.1 NC_012667:1018201-1018479 [Vibrio cholerae MJ-1236]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T23791 NC_012667:1018201-1018479 [Vibrio cholerae MJ-1236]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT23791 WP_000381183.1 NC_012667:1017920-1018204 [Vibrio cholerae MJ-1236]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT23791 NC_012667:1017920-1018204 [Vibrio cholerae MJ-1236]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References