Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1017920..1018479 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VCD_RS19360 Protein ID WP_000578476.1
Coordinates 1018201..1018479 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VCD_RS19355 Protein ID WP_000381183.1
Coordinates 1017920..1018204 (+) Length 95 a.a.

Genomic Context

VCD_RS19355VCD_RS19360VCD_RS20490VCD_RS19325VCD_RS19330VCD_RS20495VCD_RS19335VCD_RS19340VCD_RS19345VCD_RS19350VCD_RS19365VCD_RS19370VCD_RS19375VCD_RS19380VCD_RS20510VCD_RS19385VCD_RS19390VCD_RS19395VCD_RS19400
Location: 1017920..1018204 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 1018201..1018479 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 1013586..1013696 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 1013706..1014404 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 1014527..1015153 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 1015195..1015287 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 1015302..1015775 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 1015975..1016157 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 1016549..1017145 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 1017210..1017725 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 1018630..1019043 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 1019231..1019710 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 1019923..1020546 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 1020752..1021177 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 1021324..1021473 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 1021446..1021697 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 1021892..1022095 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 1022352..1022738 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 1022895..1023401 (507 bp)
Type: Others
Protein ID: WP_000393074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCD_RS204901013586..1013696-111WP_079857360.1DUF3265 domain-containing protein-
VCD_RS193251013706..1014404-699WP_001890502.1hypothetical protein-
VCD_RS193301014527..1015153-627WP_000365424.1LysE family translocator-
VCD_RS204951015195..1015287-93WP_014378730.1DUF3265 domain-containing protein-
VCD_RS193351015302..1015775-474WP_001161076.1GrpB family protein-
VCD_RS193401015975..1016157-183WP_000923182.1DUF645 family protein-
VCD_RS193451016549..1017145-597WP_000255434.1hypothetical protein-
VCD_RS193501017210..1017725-516WP_001201520.1lipocalin family protein-
VCD_RS193551017920..1018204+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VCD_RS193601018201..1018479+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
VCD_RS193651018630..1019043-414WP_000049420.1VOC family protein-
VCD_RS193701019231..1019710-480WP_000009888.1lecithin retinol acyltransferase family protein-
VCD_RS193751019923..1020546-624WP_000247070.1DUF1349 domain-containing protein-
VCD_RS193801020752..1021177-426WP_000415750.1hypothetical protein-
VCD_RS205101021324..1021473-150WP_071908333.1DUF3265 domain-containing protein-
VCD_RS193851021446..1021697-252WP_001890111.1TIGR03643 family protein-
VCD_RS193901021892..1022095-204WP_001911580.1hypothetical protein-
VCD_RS193951022352..1022738-387WP_000703163.1VOC family protein-
VCD_RS194001022895..1023401-507WP_000393074.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932253..1057432125179
insideIntegron--958376..105059692220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T23791 WP_000578476.1 NC_012667:1018201-1018479 [Vibrio cholerae MJ-1236]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T23791 NC_012667:1018201-1018479 [Vibrio cholerae MJ-1236]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT23791 WP_000381183.1 NC_012667:1017920-1018204 [Vibrio cholerae MJ-1236]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT23791 NC_012667:1017920-1018204 [Vibrio cholerae MJ-1236]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References