Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 322600..323178 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GQX72_RS15190 Protein ID WP_001180243.1
Coordinates 322600..322917 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GQX72_RS15195 Protein ID WP_000557292.1
Coordinates 322936..323178 (-) Length 81 a.a.

Genomic Context

GQX72_RS15155GQX72_RS15160GQX72_RS15165GQX72_RS15170GQX72_RS15175GQX72_RS15180GQX72_RS15200GQX72_RS15205GQX72_RS15210GQX72_RS15220GQX72_RS15225GQX72_RS15240GQX72_RS15250GQX72_RS15190GQX72_RS15195GQX72_RS15230GQX72_RS15235
Location: 318124..318306 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 318660..318842 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 319037..319714 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 319876..321084 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 321246..321950 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 322108..322446 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 323422..323808 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 323865..323978 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 323927..324208 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 324466..325002 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 325139..325654 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 326963..327088 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 327338..327784 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 322600..322917 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 322936..323178 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 325804..326301 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 326298..326570 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQX72_RS15155318124..318306+183WP_000923340.1DUF645 family protein-
GQX72_RS15160318660..318842+183WP_000923153.1DUF645 family protein-
GQX72_RS15165319037..319714+678WP_000254617.1HNH endonuclease-
GQX72_RS15170319876..321084+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
GQX72_RS15175321246..321950+705WP_000087610.1HNH endonuclease-
GQX72_RS15180322108..322446+339WP_000713853.1hypothetical protein-
GQX72_RS15190322600..322917-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GQX72_RS15195322936..323178-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GQX72_RS15200323422..323808+387WP_001015867.1NUDIX hydrolase-
GQX72_RS15205323865..323978+114WP_001900214.1hypothetical protein-
GQX72_RS15210323927..324208+282WP_001894429.1DUF1289 domain-containing protein-
GQX72_RS15220324466..325002+537WP_000469482.1GNAT family N-acetyltransferase-
GQX72_RS15225325139..325654+516WP_001201509.1lipocalin family protein-
GQX72_RS15230325804..326301-498WP_000982260.1GNAT family N-acetyltransferase-
GQX72_RS15235326298..326570-273WP_000246253.1DUF1778 domain-containing protein-
GQX72_RS15240326963..327088+126WP_001905700.1DUF645 family protein-
GQX72_RS15250327338..327784+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305960..411159105199
insideIntegron--311040..41078399743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145392 WP_001180243.1 NZ_CP047060:c322917-322600 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145392 NZ_CP062372:801194-801511 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145392 WP_000557292.1 NZ_CP047060:c323178-322936 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145392 NZ_CP062372:800982-801191 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References