145392

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 322600..323178 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GQX72_RS15190 Protein ID WP_001180243.1
Coordinates 322600..322917 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GQX72_RS15195 Protein ID WP_000557292.1
Coordinates 322936..323178 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS15155 318124..318306 + 183 WP_000923340.1 DUF645 family protein -
GQX72_RS15160 318660..318842 + 183 WP_000923153.1 DUF645 family protein -
GQX72_RS15165 319037..319714 + 678 WP_000254617.1 HNH endonuclease -
GQX72_RS15170 319876..321084 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
GQX72_RS15175 321246..321950 + 705 WP_000087610.1 HNH endonuclease -
GQX72_RS15180 322108..322446 + 339 WP_000713853.1 hypothetical protein -
GQX72_RS15190 322600..322917 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQX72_RS15195 322936..323178 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GQX72_RS15200 323422..323808 + 387 WP_001015867.1 NUDIX hydrolase -
GQX72_RS15205 323865..323978 + 114 WP_001900214.1 hypothetical protein -
GQX72_RS15210 323927..324208 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GQX72_RS15220 324466..325002 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GQX72_RS15225 325139..325654 + 516 WP_001201509.1 lipocalin family protein -
GQX72_RS15230 325804..326301 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GQX72_RS15235 326298..326570 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GQX72_RS15240 326963..327088 + 126 WP_001905700.1 DUF645 family protein -
GQX72_RS15250 327338..327784 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145392 WP_001180243.1 NZ_CP047060:c322917-322600 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145392 NZ_CP062372:801194-801511 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145392 WP_000557292.1 NZ_CP047060:c323178-322936 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145392 NZ_CP062372:800982-801191 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References