Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 769268..769901 | Replicon | chromosome |
| Accession | NZ_CP020407 | ||
| Organism | Vibrio cholerae strain FDAARGOS_223 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | A6J62_RS03555 | Protein ID | WP_000843587.1 |
| Coordinates | 769569..769901 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | A6J62_RS03550 | Protein ID | WP_000071008.1 |
| Coordinates | 769268..769582 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A6J62_RS03505 | 764322..764609 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| A6J62_RS03510 | 764599..764850 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| A6J62_RS03515 | 765064..765477 | - | 414 | WP_000049417.1 | VOC family protein | - |
| A6J62_RS03520 | 765552..765695 | - | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| A6J62_RS03525 | 765665..766066 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| A6J62_RS03530 | 766066..766758 | - | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
| A6J62_RS03535 | 766929..767201 | - | 273 | Protein_667 | CatB-related O-acetyltransferase | - |
| A6J62_RS03540 | 767269..768249 | + | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
| A6J62_RS19640 | 768374..768529 | - | 156 | WP_000751734.1 | hypothetical protein | - |
| A6J62_RS03545 | 768697..769131 | - | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
| A6J62_RS03550 | 769268..769582 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| A6J62_RS03555 | 769569..769901 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| A6J62_RS03565 | 770242..770469 | - | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
| A6J62_RS03570 | 770418..770531 | - | 114 | WP_001889158.1 | hypothetical protein | - |
| A6J62_RS03585 | 770697..770978 | - | 282 | WP_001894453.1 | DUF1289 domain-containing protein | - |
| A6J62_RS19645 | 770927..771041 | - | 115 | Protein_676 | acetyltransferase | - |
| A6J62_RS03590 | 771098..771475 | - | 378 | WP_000411109.1 | hypothetical protein | - |
| A6J62_RS03595 | 771646..771888 | - | 243 | WP_000107461.1 | hypothetical protein | - |
| A6J62_RS03600 | 772090..772476 | - | 387 | WP_000703163.1 | VOC family protein | - |
| A6J62_RS03605 | 772685..772856 | - | 172 | Protein_680 | DUF645 family protein | - |
| A6J62_RS03610 | 773174..773443 | - | 270 | WP_001198131.1 | hypothetical protein | - |
| A6J62_RS03615 | 773803..773976 | - | 174 | WP_001882305.1 | DUF3709 domain-containing protein | - |
| A6J62_RS19650 | 774257..774460 | - | 204 | WP_001911745.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 749087..881909 | 132822 | |
| inside | Integron | - | - | 749463..875103 | 125640 | ||
| flank | IS/Tn | - | - | 767269..768249 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T74622 WP_000843587.1 NZ_CP020407:c769901-769569 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T74622 NZ_CP020407:c769901-769569 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT74622 WP_000071008.1 NZ_CP020407:c769582-769268 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT74622 NZ_CP020407:c769582-769268 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|