48145

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 321340..321918 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag IR04_RS01425 Protein ID WP_001180243.1
Coordinates 321340..321657 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag IR04_RS01430 Protein ID WP_000557292.1
Coordinates 321676..321918 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR04_RS01390 316864..317046 + 183 WP_000923340.1 DUF645 family protein -
IR04_RS01400 317400..317582 + 183 WP_000923153.1 DUF645 family protein -
IR04_RS01405 317777..318454 + 678 WP_000254617.1 HNH endonuclease -
IR04_RS01410 318616..319824 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
IR04_RS01415 319986..320690 + 705 WP_000087610.1 HNH endonuclease -
IR04_RS01420 320848..321186 + 339 WP_000713853.1 hypothetical protein -
IR04_RS01425 321340..321657 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IR04_RS01430 321676..321918 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IR04_RS01435 322162..322548 + 387 WP_001015867.1 NUDIX hydrolase -
IR04_RS19160 322605..322718 + 114 WP_001900214.1 hypothetical protein -
IR04_RS01440 322667..322948 + 282 WP_001894429.1 DUF1289 domain-containing protein -
IR04_RS01450 323206..323742 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
IR04_RS01455 323879..324394 + 516 WP_001201509.1 lipocalin family protein -
IR04_RS01460 324544..325041 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
IR04_RS01465 325038..325310 - 273 WP_000246253.1 DUF1778 domain-containing protein -
IR04_RS19885 325703..325828 + 126 WP_001900195.1 DUF645 family protein -
IR04_RS19890 325844..325882 + 39 WP_106019118.1 hypothetical protein -
IR04_RS01475 326078..326524 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..409892 105192
inside Integron - - 309780..409516 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T48145 WP_001180243.1 NZ_CP009041:c321657-321340 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T48145 NZ_CP009041:c321657-321340 [Vibrio cholerae O1 biovar El Tor]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT48145 WP_000557292.1 NZ_CP009041:c321918-321676 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT48145 NZ_CP009041:c321918-321676 [Vibrio cholerae O1 biovar El Tor]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References