Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 332394..333349 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag GPY07_RS15810 Protein ID WP_000118351.1
Coordinates 332394..332927 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GPY07_RS19430 Protein ID WP_001882332.1
Coordinates 332924..333349 (-) Length 142 a.a.

Genomic Context

GPY07_RS15835GPY07_RS15840GPY07_RS15765GPY07_RS15770GPY07_RS15775GPY07_RS15780GPY07_RS15785GPY07_RS15790GPY07_RS15795GPY07_RS15800GPY07_RS15810GPY07_RS19430GPY07_RS15820GPY07_RS15825GPY07_RS15830GPY07_RS15850GPY07_RS15855GPY07_RS15860GPY07_RS15865
Location: 335266..335538 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 335535..336032 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 327718..328590 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 328765..328983 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 329047..329484 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 329603..329812 (210 bp)
Type: Others
Protein ID: Protein_290
Location: 329948..330337 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 330494..331411 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 331645..331947 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 331935..332192 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 332394..332927 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 332924..333349 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 333416..333787 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 333928..334215 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 334367..335035 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 336234..336386 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 336708..337163 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 337291..337578 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 337568..337819 (252 bp)
Type: Others
Protein ID: WP_001250179.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY07_RS15765327718..328590-873WP_000254716.1DUF3800 domain-containing protein-
GPY07_RS15770328765..328983-219WP_071908318.1GNAT family N-acetyltransferase-
GPY07_RS15775329047..329484-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
GPY07_RS15780329603..329812-210Protein_290GNAT family N-acetyltransferase-
GPY07_RS15785329948..330337-390WP_001081302.1hypothetical protein-
GPY07_RS15790330494..331411-918WP_000186333.1alpha/beta hydrolase-
GPY07_RS15795331645..331947-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY07_RS15800331935..332192-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPY07_RS15810332394..332927-534WP_000118351.1GNAT family N-acetyltransferaseToxin
GPY07_RS19430332924..333349-426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
GPY07_RS15820333416..333787-372WP_001164080.1nucleotide pyrophosphohydrolase-
GPY07_RS15825333928..334215-288WP_000426470.1hypothetical protein-
GPY07_RS15830334367..335035-669WP_000043871.1hypothetical protein-
GPY07_RS15835335266..335538+273WP_000246253.1DUF1778 domain-containing protein-
GPY07_RS15840335535..336032+498WP_000982260.1GNAT family N-acetyltransferase-
GPY07_RS15850336234..336386-153WP_001884520.1DUF645 family protein-
GPY07_RS15855336708..337163-456WP_001245327.1GNAT family N-acetyltransferase-
GPY07_RS15860337291..337578-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY07_RS15865337568..337819-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-322056..41902496968
insideIntegron--322432..41223689804
flankIS/Tn--329047..329484437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T145060 WP_000118351.1 NZ_CP046841:c332927-332394 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T145060 NZ_CP062252:c1539961-1539782 [Pseudomonas allokribbensis]
GTGAATAGCCGTTTTCTAATTGGCCAACTCGTCGCAGACGGTTGGTATCTGGTGCGGATCAAGGGTAGTCATCATCACTT
CAAGCATCCGACCAAACCTGGTCTGGTTACGGTGCCTCACCCGAAGAAAGATCTGCTCAAGAAAACGGCCATCAGTATTT
TGCAGCAGGCGTTGCTTTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT145060 WP_001882332.1 NZ_CP046841:c333349-332924 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT145060 NZ_CP062252:c1539745-1539338 [Pseudomonas allokribbensis]
ATGCTTTACCCGATCGCGATTTCAATGGGTGATGAAGGACATGCCTGGGGAGTGGAGGTGCCGGATATTCCGGGCTGCTT
CTCCGCTGGAGATGATCTGGACGACGCAATGGCCATGGCCCGAGAAGCCATCGAAGGCCACTTCGAGATTCTGGCCGAAG
ACGGTTCACCGATCCCGCCCGCCAACAAGGTCACGTTGCATGCCGCCAATCCAAAATACGCTGGCTGCACGTGGGCGTTG
GTGGACATCGATGTAACCAAATACCTGGGCAAAGCTCAGAAACTCAACATCACATTGCCGGGCTATCTACTCAATCGTAT
CGATGAATACGTGTTGCACCACCCGGAAGAGAAAAGCCGCTCCGGATTCCTGGCCTCGGCGGCGCTCAAGGTTTTGCAGC
AACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References