Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 332394..333349 | Replicon | chromosome |
| Accession | NZ_CP046841 | ||
| Organism | Vibrio cholerae strain F9993 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KM94 |
| Locus tag | GPY07_RS15810 | Protein ID | WP_000118351.1 |
| Coordinates | 332394..332927 (-) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | GPY07_RS19430 | Protein ID | WP_001882332.1 |
| Coordinates | 332924..333349 (-) | Length | 142 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY07_RS15765 | 327718..328590 | - | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
| GPY07_RS15770 | 328765..328983 | - | 219 | WP_071908318.1 | GNAT family N-acetyltransferase | - |
| GPY07_RS15775 | 329047..329484 | - | 438 | WP_000503169.1 | IS200/IS605-like element IS1004 family transposase | - |
| GPY07_RS15780 | 329603..329812 | - | 210 | Protein_290 | GNAT family N-acetyltransferase | - |
| GPY07_RS15785 | 329948..330337 | - | 390 | WP_001081302.1 | hypothetical protein | - |
| GPY07_RS15790 | 330494..331411 | - | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
| GPY07_RS15795 | 331645..331947 | - | 303 | WP_000229317.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY07_RS15800 | 331935..332192 | - | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY07_RS15810 | 332394..332927 | - | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | Toxin |
| GPY07_RS19430 | 332924..333349 | - | 426 | WP_001882332.1 | DUF1778 domain-containing protein | Antitoxin |
| GPY07_RS15820 | 333416..333787 | - | 372 | WP_001164080.1 | nucleotide pyrophosphohydrolase | - |
| GPY07_RS15825 | 333928..334215 | - | 288 | WP_000426470.1 | hypothetical protein | - |
| GPY07_RS15830 | 334367..335035 | - | 669 | WP_000043871.1 | hypothetical protein | - |
| GPY07_RS15835 | 335266..335538 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| GPY07_RS15840 | 335535..336032 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| GPY07_RS15850 | 336234..336386 | - | 153 | WP_001884520.1 | DUF645 family protein | - |
| GPY07_RS15855 | 336708..337163 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
| GPY07_RS15860 | 337291..337578 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY07_RS15865 | 337568..337819 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 322056..419024 | 96968 | |
| inside | Integron | - | - | 322432..412236 | 89804 | ||
| flank | IS/Tn | - | - | 329047..329484 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20171.46 Da Isoelectric Point: 9.1432
>T145060 WP_000118351.1 NZ_CP046841:c332927-332394 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
Download Length: 534 bp
>T145060 NZ_CP062252:c1539961-1539782 [Pseudomonas allokribbensis]
GTGAATAGCCGTTTTCTAATTGGCCAACTCGTCGCAGACGGTTGGTATCTGGTGCGGATCAAGGGTAGTCATCATCACTT
CAAGCATCCGACCAAACCTGGTCTGGTTACGGTGCCTCACCCGAAGAAAGATCTGCTCAAGAAAACGGCCATCAGTATTT
TGCAGCAGGCGTTGCTTTGA
GTGAATAGCCGTTTTCTAATTGGCCAACTCGTCGCAGACGGTTGGTATCTGGTGCGGATCAAGGGTAGTCATCATCACTT
CAAGCATCCGACCAAACCTGGTCTGGTTACGGTGCCTCACCCGAAGAAAGATCTGCTCAAGAAAACGGCCATCAGTATTT
TGCAGCAGGCGTTGCTTTGA
Antitoxin
Download Length: 142 a.a. Molecular weight: 15714.41 Da Isoelectric Point: 7.6659
>AT145060 WP_001882332.1 NZ_CP046841:c333349-332924 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK
Download Length: 426 bp
>AT145060 NZ_CP062252:c1539745-1539338 [Pseudomonas allokribbensis]
ATGCTTTACCCGATCGCGATTTCAATGGGTGATGAAGGACATGCCTGGGGAGTGGAGGTGCCGGATATTCCGGGCTGCTT
CTCCGCTGGAGATGATCTGGACGACGCAATGGCCATGGCCCGAGAAGCCATCGAAGGCCACTTCGAGATTCTGGCCGAAG
ACGGTTCACCGATCCCGCCCGCCAACAAGGTCACGTTGCATGCCGCCAATCCAAAATACGCTGGCTGCACGTGGGCGTTG
GTGGACATCGATGTAACCAAATACCTGGGCAAAGCTCAGAAACTCAACATCACATTGCCGGGCTATCTACTCAATCGTAT
CGATGAATACGTGTTGCACCACCCGGAAGAGAAAAGCCGCTCCGGATTCCTGGCCTCGGCGGCGCTCAAGGTTTTGCAGC
AACGTTGA
ATGCTTTACCCGATCGCGATTTCAATGGGTGATGAAGGACATGCCTGGGGAGTGGAGGTGCCGGATATTCCGGGCTGCTT
CTCCGCTGGAGATGATCTGGACGACGCAATGGCCATGGCCCGAGAAGCCATCGAAGGCCACTTCGAGATTCTGGCCGAAG
ACGGTTCACCGATCCCGCCCGCCAACAAGGTCACGTTGCATGCCGCCAATCCAAAATACGCTGGCTGCACGTGGGCGTTG
GTGGACATCGATGTAACCAAATACCTGGGCAAAGCTCAGAAACTCAACATCACATTGCCGGGCTATCTACTCAATCGTAT
CGATGAATACGTGTTGCACCACCCGGAAGAGAAAAGCCGCTCCGGATTCCTGGCCTCGGCGGCGCTCAAGGTTTTGCAGC
AACGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|