Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 957028..957661 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag FDZ90_RS19180 Protein ID WP_000843587.1
Coordinates 957028..957360 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FDZ90_RS19185 Protein ID WP_000071008.1
Coordinates 957347..957661 (+) Length 105 a.a.

Genomic Context

FDZ90_RS19120FDZ90_RS19125FDZ90_RS19130FDZ90_RS19135FDZ90_RS19140FDZ90_RS19145FDZ90_RS19150FDZ90_RS19155FDZ90_RS19160FDZ90_RS19165FDZ90_RS19170FDZ90_RS19175FDZ90_RS19180FDZ90_RS19185FDZ90_RS19190FDZ90_RS19195FDZ90_RS19205FDZ90_RS19210FDZ90_RS19215FDZ90_RS19220FDZ90_RS19225FDZ90_RS19230FDZ90_RS19235FDZ90_RS19200
Location: 952471..952674 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 952955..953128 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 953488..953757 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 954068..954154 (87 bp)
Type: Others
Protein ID: WP_134820423.1
Location: 954154..954246 (93 bp)
Type: Others
Protein ID: Protein_881
Location: 954455..954841 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 955043..955285 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 955455..955832 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 955889..956003 (115 bp)
Type: Others
Protein ID: Protein_885
Location: 955952..956233 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 956398..956511 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 956460..956687 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 957028..957360 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 957347..957661 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 957798..958232 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 958400..958555 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 959727..959999 (273 bp)
Type: Others
Protein ID: Protein_894
Location: 960170..960862 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 960862..961263 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 961233..961376 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 961451..961864 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 962078..962329 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 962319..962606 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 958680..959659 (980 bp)
Type: Others
Protein ID: Protein_893
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FDZ90_RS19120952471..952674+204WP_001911745.1hypothetical protein-
FDZ90_RS19125952955..953128+174WP_001882305.1DUF3709 domain-containing protein-
FDZ90_RS19130953488..953757+270WP_001198131.1hypothetical protein-
FDZ90_RS19135954068..954154+87WP_134820423.1DUF645 family protein-
FDZ90_RS19140954154..954246+93Protein_881DUF645 family protein-
FDZ90_RS19145954455..954841+387WP_000703163.1VOC family protein-
FDZ90_RS19150955043..955285+243WP_000107461.1hypothetical protein-
FDZ90_RS19155955455..955832+378WP_000411109.1hypothetical protein-
FDZ90_RS19160955889..956003+115Protein_885acetyltransferase-
FDZ90_RS19165955952..956233+282WP_001894453.1DUF1289 domain-containing protein-
FDZ90_RS19170956398..956511+114WP_001889158.1hypothetical protein-
FDZ90_RS19175956460..956687+228WP_001894457.1DUF1289 domain-containing protein-
FDZ90_RS19180957028..957360+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FDZ90_RS19185957347..957661+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
FDZ90_RS19190957798..958232+435WP_000256036.1GNAT family N-acetyltransferase-
FDZ90_RS19195958400..958555+156WP_000751734.1hypothetical protein-
FDZ90_RS19200958680..959659-980Protein_893IS5-like element ISVch5 family transposase-
FDZ90_RS19205959727..959999+273Protein_894CatB-related O-acetyltransferase-
FDZ90_RS19210960170..960862+693WP_001047169.1GNAT family N-acetyltransferase-
FDZ90_RS19215960862..961263+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
FDZ90_RS19220961233..961376+144WP_071908341.1DUF3265 domain-containing protein-
FDZ90_RS19225961451..961864+414WP_000049417.1VOC family protein-
FDZ90_RS19230962078..962329+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FDZ90_RS19235962319..962606+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-882589..97784095251
insideIntegroncatB9-887669..97746489795
flankIS/Tn--958940..959659719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T125044 WP_000843587.1 NZ_CP040173:957028-957360 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T125044 NZ_CP040173:957028-957360 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT125044 WP_000071008.1 NZ_CP040173:957347-957661 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT125044 NZ_CP040173:957347-957661 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References