46754

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 75934..76472 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag EN18_RS14615 Protein ID WP_000802136.1
Coordinates 75934..76233 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag EN18_RS14620 Protein ID WP_001107719.1
Coordinates 76230..76472 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EN18_RS14580 71869..72051 + 183 WP_000923182.1 DUF645 family protein -
EN18_RS14585 72251..72724 + 474 WP_001161076.1 GrpB family protein -
EN18_RS20575 72739..72831 + 93 WP_014378730.1 DUF3265 domain-containing protein -
EN18_RS14590 72873..73499 + 627 WP_000365424.1 LysE family translocator -
EN18_RS14595 73622..74320 + 699 WP_001890502.1 hypothetical protein -
EN18_RS20580 74330..74440 + 111 WP_079857360.1 DUF3265 domain-containing protein -
EN18_RS14605 75018..75197 + 180 WP_001883058.1 DUF645 family protein -
EN18_RS14610 75411..75806 + 396 WP_000870857.1 DUF3465 domain-containing protein -
EN18_RS14615 75934..76233 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EN18_RS14620 76230..76472 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
EN18_RS20085 76701..77279 + 579 WP_000110120.1 hypothetical protein -
EN18_RS20590 77301..77393 + 93 WP_014164112.1 DUF3265 domain-containing protein -
EN18_RS14635 77817..78500 + 684 WP_000877436.1 hypothetical protein -
EN18_RS14640 78714..78980 + 267 WP_000937852.1 hypothetical protein -
EN18_RS14645 79135..79734 + 600 WP_000429495.1 hypothetical protein -
EN18_RS14650 80015..80950 + 936 WP_000051985.1 restriction endonuclease -
EN18_RS20605 80916..81056 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31037..137542 106505
inside Integron - - 36117..137166 101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T46754 WP_000802136.1 NZ_CP007635:c76233-75934 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T46754 NZ_CP007635:c76233-75934 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT46754 WP_001107719.1 NZ_CP007635:c76472-76230 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT46754 NZ_CP007635:c76472-76230 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References