145404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 397183..397949 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GQX72_RS15920 Protein ID WP_000982260.1
Coordinates 397183..397680 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GQX72_RS15925 Protein ID WP_000246253.1
Coordinates 397677..397949 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS15870 393045..393351 + 307 Protein_404 CatB-related O-acetyltransferase -
GQX72_RS15875 393488..394180 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
GQX72_RS15880 394180..394581 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GQX72_RS15885 394551..394694 + 144 WP_071908341.1 DUF3265 domain-containing protein -
GQX72_RS15890 394769..395182 + 414 WP_000049417.1 VOC family protein -
GQX72_RS15895 395396..395647 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GQX72_RS15900 395637..395924 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
GQX72_RS15905 396052..396507 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GQX72_RS15910 396829..396981 + 153 WP_001884520.1 DUF645 family protein -
GQX72_RS15920 397183..397680 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GQX72_RS15925 397677..397949 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
GQX72_RS15930 398180..398848 + 669 WP_000043871.1 hypothetical protein -
GQX72_RS15935 399000..399287 + 288 WP_000426470.1 hypothetical protein -
GQX72_RS15940 399428..399799 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GQX72_RS19055 399866..400291 + 426 WP_001882332.1 DUF1778 domain-containing protein -
GQX72_RS15950 400288..400821 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
GQX72_RS15960 401023..401280 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GQX72_RS15965 401268..401570 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
GQX72_RS15970 401804..402721 + 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743
flank IS/Tn - - 391997..392977 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145404 WP_000982260.1 NZ_CP047060:c397680-397183 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145404 NZ_CP062376:2328313-2328579 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145404 WP_000246253.1 NZ_CP047060:c397949-397677 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145404 NZ_CP062376:2328062-2328313 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References