145880

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) DhiAT/-
Location 406415..407199 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GTF75_RS16085 Protein ID WP_001114075.1
Coordinates 406415..406684 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag GTF75_RS16090 Protein ID WP_000921691.1
Coordinates 406678..407199 (+) Length 174 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF75_RS16045 401781..402698 + 918 WP_000186333.1 alpha/beta hydrolase -
GTF75_RS16050 402855..403244 + 390 WP_001081302.1 hypothetical protein -
GTF75_RS16055 403380..403589 + 210 Protein_430 GNAT family N-acetyltransferase -
GTF75_RS16060 403708..404145 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GTF75_RS16065 404209..404427 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GTF75_RS16070 404602..405474 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GTF75_RS16075 405624..406223 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GTF75_RS16080 406280..406384 + 105 WP_099607150.1 acetyltransferase -
GTF75_RS16085 406415..406684 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
GTF75_RS16090 406678..407199 + 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
GTF75_RS16095 407498..407623 + 126 WP_001905700.1 DUF645 family protein -
GTF75_RS16100 407874..408269 + 396 WP_001000867.1 hypothetical protein -
GTF75_RS16105 408408..408686 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GTF75_RS16110 408683..408967 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GTF75_RS16115 409161..409676 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
GTF75_RS16120 409733..409828 + 96 WP_099607151.1 acetyltransferase -
GTF75_RS16125 409860..410273 + 414 WP_000049420.1 VOC family protein -
GTF75_RS16130 410280..410412 - 133 Protein_445 hypothetical protein -
GTF75_RS16135 410828..412005 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305935..411136 105201
inside Integron - - 311015..410760 99745
flank IS/Tn - - 403708..404145 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-74)

Antitoxin

(4-59)


Sequences


Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T145880 WP_001114075.1 NZ_CP047302:406415-406684 [Vibrio cholerae O1 biovar El Tor]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T145880 NZ_CP047302:406415-406684 [Vibrio cholerae O1 biovar El Tor]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT145880 WP_000921691.1 NZ_CP047302:406678-407199 [Vibrio cholerae O1 biovar El Tor]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT145880 NZ_CP047302:406678-407199 [Vibrio cholerae O1 biovar El Tor]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A086SLD6


Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References