Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 406415..407199 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GTF75_RS16085 Protein ID WP_001114075.1
Coordinates 406415..406684 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag GTF75_RS16090 Protein ID WP_000921691.1
Coordinates 406678..407199 (+) Length 174 a.a.

Genomic Context

GTF75_RS16045GTF75_RS16050GTF75_RS16055GTF75_RS16060GTF75_RS16065GTF75_RS16070GTF75_RS16075GTF75_RS16080GTF75_RS16085GTF75_RS16090GTF75_RS16095GTF75_RS16100GTF75_RS16115GTF75_RS16120GTF75_RS16125GTF75_RS16135GTF75_RS16105GTF75_RS16110GTF75_RS16130
Location: 401781..402698 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 402855..403244 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 403380..403589 (210 bp)
Type: Others
Protein ID: Protein_430
Location: 403708..404145 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 404209..404427 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 404602..405474 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 405624..406223 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 406280..406384 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 406415..406684 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 406678..407199 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 407498..407623 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 407874..408269 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 409161..409676 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 409733..409828 (96 bp)
Type: Others
Protein ID: WP_099607151.1
Location: 409860..410273 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 410828..412005 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 408408..408686 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 408683..408967 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 410280..410412 (133 bp)
Type: Others
Protein ID: Protein_445
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF75_RS16045401781..402698+918WP_000186333.1alpha/beta hydrolase-
GTF75_RS16050402855..403244+390WP_001081302.1hypothetical protein-
GTF75_RS16055403380..403589+210Protein_430GNAT family N-acetyltransferase-
GTF75_RS16060403708..404145+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
GTF75_RS16065404209..404427+219WP_071908318.1GNAT family N-acetyltransferase-
GTF75_RS16070404602..405474+873WP_000254716.1DUF3800 domain-containing protein-
GTF75_RS16075405624..406223+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GTF75_RS16080406280..406384+105WP_099607150.1acetyltransferase-
GTF75_RS16085406415..406684+270WP_001114075.1DUF4160 domain-containing proteinToxin
GTF75_RS16090406678..407199+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
GTF75_RS16095407498..407623+126WP_001905700.1DUF645 family protein-
GTF75_RS16100407874..408269+396WP_001000867.1hypothetical protein-
GTF75_RS16105408408..408686-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
GTF75_RS16110408683..408967-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
GTF75_RS16115409161..409676+516WP_000343779.1GNAT family N-acetyltransferase-
GTF75_RS16120409733..409828+96WP_099607151.1acetyltransferase-
GTF75_RS16125409860..410273+414WP_000049420.1VOC family protein-
GTF75_RS16130410280..410412-133Protein_445hypothetical protein-
GTF75_RS16135410828..412005+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305935..411136105201
insideIntegron--311015..41076099745
flankIS/Tn--403708..404145437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T145880 WP_001114075.1 NZ_CP047302:406415-406684 [Vibrio cholerae O1 biovar El Tor]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T145880 NZ_CP047302:406415-406684 [Vibrio cholerae O1 biovar El Tor]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT145880 WP_000921691.1 NZ_CP047302:406678-407199 [Vibrio cholerae O1 biovar El Tor]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT145880 NZ_CP047302:406678-407199 [Vibrio cholerae O1 biovar El Tor]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References