Detailed information of TA system TA038630

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 103888..104435
• Replicon: chromosome
• Accession: NZ_AP024548
• Organism: Vibrio cholerae strain BCH-01536

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q9KM92
• Locus tag: K6J77_RS14710
• Protein ID: WP_000229317.1
• Coordinates: 104133..104435 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: K6J77_RS14705
• Protein ID: WP_000861987.1
• Coordinates: 103888..104145 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J77_RS14660	98917..99372	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-
K6J77_RS19095	99429..99551	+	123	Protein_188	acetyltransferase	-
K6J77_RS14665	99722..99846	+	125	Protein_189	DUF645 family protein	-
K6J77_RS19100	99963..100031	+	69	Protein_190	acetyltransferase	-
K6J77_RS14670	100048..100545	-	498	WP_000982260.1	GNAT family N-acetyltransferase	-
K6J77_RS14675	100542..100814	-	273	WP_000246253.1	DUF1778 domain-containing protein	-
K6J77_RS19105	100966..101028	+	63	Protein_193	acetyltransferase	-
K6J77_RS14680	101045..101713	+	669	WP_000043871.1	hypothetical protein	-
K6J77_RS14685	101865..102152	+	288	WP_000426470.1	hypothetical protein	-
K6J77_RS14690	102293..102664	+	372	WP_001164080.1	MazG nucleotide pyrophosphohydrolase domain-containing protein	-
K6J77_RS19110	102887..103156	+	270	WP_000179600.1	DUF1778 domain-containing protein	-
K6J77_RS14700	103153..103686	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
K6J77_RS19115	103696..103806	+	111	WP_086010065.1	DUF3265 domain-containing protein	-
K6J77_RS14705	103888..104145	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K6J77_RS14710	104133..104435	+	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K6J77_RS14715	104669..105586	+	918	WP_000186333.1	alpha/beta hydrolase	-
K6J77_RS14720	105743..106132	+	390	WP_001081302.1	hypothetical protein	-
K6J77_RS14725	106268..106477	+	210	Protein_204	GNAT family N-acetyltransferase	-
K6J77_RS14730	106596..107033	+	438	WP_000503169.1	IS200/IS605-like element IS1004 family transposase	-
K6J77_RS14735	107094..107315	+	222	Protein_206	GNAT family N-acetyltransferase	-
K6J77_RS14740	107490..108362	+	873	WP_000254716.1	DUF3800 domain-containing protein	-
K6J77_RS14745	108512..109111	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
K6J77_RS14750	109168..109236	+	69	Protein_209	acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	-	-	11978..113648	101670
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0	flank	IS/Tn	-	-	106596..107033	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11726.68 Da
• Isoelectric Point: 5.1972

>T38630 WP_000229317.1 NZ_AP024548:104133-104435 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T38630 NZ_AP024548:104133-104435 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT38630 WP_000861987.1 NZ_AP024548:103888-104145 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT38630 NZ_AP024548:103888-104145 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Structures

Toxin

• AlphaFold DB: Q9KM92

Antitoxin

• AlphaFold DB: A0A1T4SLM9