Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 774472..775050 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag NW313_RS17545 Protein ID WP_001180243.1
Coordinates 774472..774789 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag NW313_RS17550 Protein ID WP_000557292.1
Coordinates 774808..775050 (-) Length 81 a.a.

Genomic Context

NW313_RS17485NW313_RS17490NW313_RS17495NW313_RS17500NW313_RS17505NW313_RS17510NW313_RS17515NW313_RS17520NW313_RS17525NW313_RS17530NW313_RS17535NW313_RS17540NW313_RS17555NW313_RS17560NW313_RS17565NW313_RS17570NW313_RS17575NW313_RS17580NW313_RS17585NW313_RS17590NW313_RS17595NW313_RS17600NW313_RS17605NW313_RS17610NW313_RS17615NW313_RS17620NW313_RS17545NW313_RS17550
Location: 769702..770058 (357 bp)
Type: Others
Protein ID: WP_001094969.1
Location: 770157..770300 (144 bp)
Type: Others
Protein ID: Protein_721
Location: 770423..770542 (120 bp)
Type: Others
Protein ID: WP_001900954.1
Location: 770758..771114 (357 bp)
Type: Others
Protein ID: WP_001094970.1
Location: 771258..771794 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 772145..772207 (63 bp)
Type: Others
Protein ID: Protein_725
Location: 772197..772307 (111 bp)
Type: Others
Protein ID: WP_223804330.1
Location: 772466..772891 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 773040..773387 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 773534..773827 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 773890..774065 (176 bp)
Type: Others
Protein ID: Protein_730
Location: 774126..774278 (153 bp)
Type: Others
Protein ID: Protein_731
Location: 775292..775801 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 775858..776511 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 776600..776809 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 776821..777039 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 777228..777421 (194 bp)
Type: Others
Protein ID: Protein_738
Location: 777442..777675 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 778100..778280 (181 bp)
Type: Others
Protein ID: Protein_740
Location: 778393..778506 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 778547..778834 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 778845..779162 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 779159..779269 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 779308..779418 (111 bp)
Type: Others
Protein ID: Protein_745
Location: 779446..779571 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 779534..779650 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 774472..774789 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 774808..775050 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NW313_RS17485769702..770058+357WP_001094969.1DUF6404 family protein-
NW313_RS17490770157..770300+144Protein_721acetyltransferase-
NW313_RS17495770423..770542+120WP_001900954.1DUF645 family protein-
NW313_RS17500770758..771114+357WP_001094970.1DUF6404 family protein-
NW313_RS17505771258..771794+537WP_000644491.1nucleotidyltransferase family protein-
NW313_RS17510772145..772207+63Protein_725DUF645 family protein-
NW313_RS17515772197..772307+111WP_223804330.1Tfp pilus assembly protein-
NW313_RS17520772466..772891+426WP_000403014.1GNAT family N-acetyltransferase-
NW313_RS17525773040..773387+348WP_000933409.1hypothetical protein-
NW313_RS17530773534..773827+294WP_125460920.1hypothetical protein-
NW313_RS17535773890..774065+176Protein_730acetyltransferase-
NW313_RS17540774126..774278+153Protein_731DUF645 family protein-
NW313_RS17545774472..774789-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NW313_RS17550774808..775050-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
NW313_RS17555775292..775801+510WP_000405987.1GNAT family N-acetyltransferase-
NW313_RS17560775858..776511+654WP_000226874.1hypothetical protein-
NW313_RS17565776600..776809+210WP_001900246.1DUF3709 domain-containing protein-
NW313_RS17570776821..777039+219WP_001917086.1DUF3709 domain-containing protein-
NW313_RS17575777228..777421+194Protein_738hypothetical protein-
NW313_RS17580777442..777675+234WP_032482776.1DUF3709 domain-containing protein-
NW313_RS17585778100..778280+181Protein_740DUF645 family protein-
NW313_RS17590778393..778506+114WP_001894955.1hypothetical protein-
NW313_RS17595778547..778834+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
NW313_RS17600778845..779162+318WP_001232701.1HigA family addiction module antitoxin-
NW313_RS17605779159..779269+111WP_134814058.1DUF3265 domain-containing protein-
NW313_RS17610779308..779418+111Protein_745acetyltransferase-
NW313_RS17615779446..779571+126WP_001944767.1DUF645 family protein-
NW313_RS17620779534..779650+117WP_001889170.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-713852..820357106505
insideIntegroncatB9-718932..819981101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T254471 WP_001180243.1 NZ_CP102928:c774789-774472 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT254471 WP_000557292.1 NZ_CP102928:c775050-774808 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References