58379

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 150384..150922 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ83_RS14945 Protein ID WP_000802136.1
Coordinates 150384..150683 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ83_RS14950 Protein ID WP_001107719.1
Coordinates 150680..150922 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ83_RS14895 146319..146501 + 183 WP_000923182.1 DUF645 family protein -
ASZ83_RS14900 146701..147174 + 474 WP_001161076.1 GrpB family protein -
ASZ83_RS14905 147189..147281 + 93 WP_014378730.1 DUF3265 domain-containing protein -
ASZ83_RS14910 147323..147949 + 627 WP_000365424.1 LysE family translocator -
ASZ83_RS14915 148072..148770 + 699 WP_001890502.1 hypothetical protein -
ASZ83_RS14920 148780..148890 + 111 WP_079857360.1 DUF3265 domain-containing protein -
ASZ83_RS14935 149468..149647 + 180 WP_001883058.1 DUF645 family protein -
ASZ83_RS14940 149861..150256 + 396 WP_000870857.1 DUF3465 domain-containing protein -
ASZ83_RS14945 150384..150683 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ83_RS14950 150680..150922 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ASZ83_RS14955 151151..151729 + 579 WP_000110120.1 hypothetical protein -
ASZ83_RS14960 151751..151843 + 93 WP_014164112.1 DUF3265 domain-containing protein -
ASZ83_RS14970 152267..152950 + 684 WP_000877436.1 hypothetical protein -
ASZ83_RS14975 153164..153430 + 267 WP_000937852.1 hypothetical protein -
ASZ83_RS14980 153585..154184 + 600 WP_000429495.1 hypothetical protein -
ASZ83_RS14985 154465..155400 + 936 WP_000051985.1 restriction endonuclease -
ASZ83_RS14990 155366..155506 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 87981..224211 136230
inside Integron - - 93061..221594 128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58379 WP_000802136.1 NZ_CP013316:c150683-150384 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58379 NZ_CP013316:c150683-150384 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58379 WP_001107719.1 NZ_CP013316:c150922-150680 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58379 NZ_CP013316:c150922-150680 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References