Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 150384..150922 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ83_RS14945 Protein ID WP_000802136.1
Coordinates 150384..150683 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ83_RS14950 Protein ID WP_001107719.1
Coordinates 150680..150922 (-) Length 81 a.a.

Genomic Context

ASZ83_RS14895ASZ83_RS14900ASZ83_RS14905ASZ83_RS14910ASZ83_RS14915ASZ83_RS14920ASZ83_RS14935ASZ83_RS14940ASZ83_RS14955ASZ83_RS14960ASZ83_RS14970ASZ83_RS14975ASZ83_RS14980ASZ83_RS14985ASZ83_RS14990ASZ83_RS14945ASZ83_RS14950
Location: 146319..146501 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 146701..147174 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 147189..147281 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 147323..147949 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 148072..148770 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 148780..148890 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 149468..149647 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 149861..150256 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 151151..151729 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 151751..151843 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 152267..152950 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 153164..153430 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 153585..154184 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 154465..155400 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 155366..155506 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 150384..150683 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 150680..150922 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS14895146319..146501+183WP_000923182.1DUF645 family protein-
ASZ83_RS14900146701..147174+474WP_001161076.1GrpB family protein-
ASZ83_RS14905147189..147281+93WP_014378730.1DUF3265 domain-containing protein-
ASZ83_RS14910147323..147949+627WP_000365424.1LysE family translocator-
ASZ83_RS14915148072..148770+699WP_001890502.1hypothetical protein-
ASZ83_RS14920148780..148890+111WP_079857360.1DUF3265 domain-containing protein-
ASZ83_RS14935149468..149647+180WP_001883058.1DUF645 family protein-
ASZ83_RS14940149861..150256+396WP_000870857.1DUF3465 domain-containing protein-
ASZ83_RS14945150384..150683-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ83_RS14950150680..150922-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
ASZ83_RS14955151151..151729+579WP_000110120.1hypothetical protein-
ASZ83_RS14960151751..151843+93WP_014164112.1DUF3265 domain-containing protein-
ASZ83_RS14970152267..152950+684WP_000877436.1hypothetical protein-
ASZ83_RS14975153164..153430+267WP_000937852.1hypothetical protein-
ASZ83_RS14980153585..154184+600WP_000429495.1hypothetical protein-
ASZ83_RS14985154465..155400+936WP_000051985.1restriction endonuclease-
ASZ83_RS14990155366..155506+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58379 WP_000802136.1 NZ_CP013316:c150683-150384 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58379 NZ_CP013316:c150683-150384 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58379 WP_001107719.1 NZ_CP013316:c150922-150680 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58379 NZ_CP013316:c150922-150680 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References