Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 810221..810768 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag NW313_RS17925 Protein ID WP_000229317.1
Coordinates 810466..810768 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag NW313_RS17920 Protein ID WP_000861987.1
Coordinates 810221..810478 (+) Length 86 a.a.

Genomic Context

NW313_RS17855NW313_RS17860NW313_RS17865NW313_RS17870NW313_RS17885NW313_RS17890NW313_RS17895NW313_RS17900NW313_RS17905NW313_RS17910NW313_RS17915NW313_RS17920NW313_RS17925NW313_RS17930NW313_RS17935NW313_RS17940NW313_RS17945NW313_RS17950NW313_RS17955NW313_RS17960NW313_RS17965NW313_RS17875NW313_RS17880
Location: 805250..805705 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 805762..805884 (123 bp)
Type: Others
Protein ID: Protein_795
Location: 806055..806179 (125 bp)
Type: Others
Protein ID: Protein_796
Location: 806296..806364 (69 bp)
Type: Others
Protein ID: Protein_797
Location: 807299..807361 (63 bp)
Type: Others
Protein ID: Protein_800
Location: 807378..808046 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 808198..808485 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 808626..808997 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 809220..809489 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 809486..810019 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 810029..810139 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 810221..810478 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 810466..810768 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 811002..811919 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 812076..812465 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 812601..812810 (210 bp)
Type: Others
Protein ID: Protein_811
Location: 812929..813366 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 813427..813648 (222 bp)
Type: Others
Protein ID: Protein_813
Location: 813823..814695 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 814845..815444 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 815501..815569 (69 bp)
Type: Others
Protein ID: Protein_816
Location: 806381..806878 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 806875..807147 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NW313_RS17855805250..805705+456WP_001245327.1GNAT family N-acetyltransferase-
NW313_RS17860805762..805884+123Protein_795acetyltransferase-
NW313_RS17865806055..806179+125Protein_796DUF645 family protein-
NW313_RS17870806296..806364+69Protein_797acetyltransferase-
NW313_RS17875806381..806878-498WP_000982260.1GNAT family N-acetyltransferase-
NW313_RS17880806875..807147-273WP_000246253.1DUF1778 domain-containing protein-
NW313_RS17885807299..807361+63Protein_800acetyltransferase-
NW313_RS17890807378..808046+669WP_000043871.1hypothetical protein-
NW313_RS17895808198..808485+288WP_000426470.1hypothetical protein-
NW313_RS17900808626..808997+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
NW313_RS17905809220..809489+270WP_000179600.1DUF1778 domain-containing protein-
NW313_RS17910809486..810019+534WP_000118351.1GNAT family N-acetyltransferase-
NW313_RS17915810029..810139+111WP_086010065.1DUF3265 domain-containing protein-
NW313_RS17920810221..810478+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
NW313_RS17925810466..810768+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NW313_RS17930811002..811919+918WP_000186333.1alpha/beta hydrolase-
NW313_RS17935812076..812465+390WP_001081302.1hypothetical protein-
NW313_RS17940812601..812810+210Protein_811GNAT family N-acetyltransferase-
NW313_RS17945812929..813366+438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
NW313_RS17950813427..813648+222Protein_813GNAT family N-acetyltransferase-
NW313_RS17955813823..814695+873WP_000254716.1DUF3800 domain-containing protein-
NW313_RS17960814845..815444+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
NW313_RS17965815501..815569+69Protein_816acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-713852..820357106505
insideIntegroncatB9-718932..819981101049
flankIS/Tn--812929..813366437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T254479 WP_000229317.1 NZ_CP102928:810466-810768 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT254479 WP_000861987.1 NZ_CP102928:810221-810478 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References