Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 419998..420526 Replicon chromosome
Accession NZ_LT907990
Organism Vibrio cholerae strain A19

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag ALC86_RS16445 Protein ID WP_000221354.1
Coordinates 420239..420526 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag ALC86_RS16440 Protein ID WP_001250179.1
Coordinates 419998..420249 (+) Length 84 a.a.

Genomic Context

ALC86_RS16395ALC86_RS16400ALC86_RS19610ALC86_RS16415ALC86_RS16420ALC86_RS16425ALC86_RS16430ALC86_RS16435ALC86_RS16440ALC86_RS16445ALC86_RS16450ALC86_RS16460ALC86_RS16485ALC86_RS16490ALC86_RS16495ALC86_RS19780ALC86_RS16505ALC86_RS16410ALC86_RS16470ALC86_RS16475
Location: 415266..415580 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 415717..416151 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 416319..416474 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 417647..417953 (307 bp)
Type: Others
Protein ID: Protein_446
Location: 418090..418782 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 418782..419183 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419153..419296 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419371..419784 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 419998..420249 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 420239..420526 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 420654..421109 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421431..421583 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 422782..423450 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 423602..423889 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424030..424401 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424468..424893 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 424890..425423 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 416599..417579 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 421785..422282 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422279..422551 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ALC86_RS16395415266..415580+315WP_000071008.1DNA-binding transcriptional regulator-
ALC86_RS16400415717..416151+435WP_000256036.1GNAT family N-acetyltransferase-
ALC86_RS19610416319..416474+156WP_000751734.1hypothetical protein-
ALC86_RS16410416599..417579-981WP_000019370.1IS5-like element ISVch5 family transposase-
ALC86_RS16415417647..417953+307Protein_446CatB-related O-acetyltransferase-
ALC86_RS16420418090..418782+693WP_001047169.1GNAT family N-acetyltransferase-
ALC86_RS16425418782..419183+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ALC86_RS16430419153..419296+144WP_071908341.1DUF3265 domain-containing protein-
ALC86_RS16435419371..419784+414WP_000049417.1VOC family protein-
ALC86_RS16440419998..420249+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ALC86_RS16445420239..420526+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ALC86_RS16450420654..421109+456WP_001245327.1GNAT family N-acetyltransferase-
ALC86_RS16460421431..421583+153WP_001884520.1DUF645 family protein-
ALC86_RS16470421785..422282-498WP_000982260.1GNAT family N-acetyltransferase-
ALC86_RS16475422279..422551-273WP_000246253.1DUF1778 domain-containing protein-
ALC86_RS16485422782..423450+669WP_000043871.1hypothetical protein-
ALC86_RS16490423602..423889+288WP_000426470.1hypothetical protein-
ALC86_RS16495424030..424401+372WP_001164080.1nucleotide pyrophosphohydrolase-
ALC86_RS19780424468..424893+426WP_001882332.1DUF1778 domain-containing protein-
ALC86_RS16505424890..425423+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639
flankIS/Tn--416599..417579980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T293832 WP_000221354.1 NZ_LT907990:420239-420526 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT293832 WP_001250179.1 NZ_LT907990:419998-420249 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References