58362

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 447650..448283 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag ASZ79_RS16860 Protein ID WP_000843587.1
Coordinates 447650..447982 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASZ79_RS16865 Protein ID WP_000071008.1
Coordinates 447969..448283 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ79_RS20925 443091..443294 + 204 WP_001911745.1 hypothetical protein -
ASZ79_RS20735 443575..443748 + 174 WP_001882305.1 DUF3709 domain-containing protein -
ASZ79_RS16800 444108..444377 + 270 WP_001198131.1 hypothetical protein -
ASZ79_RS21085 444695..444866 + 172 Protein_486 DUF645 family protein -
ASZ79_RS16815 445075..445461 + 387 WP_000703163.1 VOC family protein -
ASZ79_RS16820 445663..445905 + 243 WP_000107461.1 hypothetical protein -
ASZ79_RS16825 446076..446453 + 378 WP_000411109.1 hypothetical protein -
ASZ79_RS21050 446510..446624 + 115 Protein_490 acetyltransferase -
ASZ79_RS16830 446573..446854 + 282 WP_001894453.1 DUF1289 domain-containing protein -
ASZ79_RS16845 447020..447133 + 114 WP_001889158.1 hypothetical protein -
ASZ79_RS16850 447082..447309 + 228 WP_001894457.1 DUF1289 domain-containing protein -
ASZ79_RS16860 447650..447982 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ79_RS16865 447969..448283 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
ASZ79_RS16870 448420..448854 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
ASZ79_RS20835 449022..449177 + 156 WP_000751734.1 hypothetical protein -
ASZ79_RS16885 449302..450282 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
ASZ79_RS16890 450350..450656 + 307 Protein_499 CatB-related O-acetyltransferase -
ASZ79_RS16895 450793..451485 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
ASZ79_RS16900 451485..451886 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
ASZ79_RS20750 451856..451999 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ASZ79_RS16910 452074..452487 + 414 WP_000049417.1 VOC family protein -
ASZ79_RS16915 452701..452952 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ79_RS16920 452942..453229 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..468464 163764
inside Integron - - 309780..468088 158308
flank IS/Tn - - 449302..450282 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-100)

Antitoxin

(43-92)


Sequences


Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T58362 WP_000843587.1 NZ_CP013314:447650-447982 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T58362 NZ_CP013314:447650-447982 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT58362 WP_000071008.1 NZ_CP013314:447969-448283 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT58362 NZ_CP013314:447969-448283 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA


Antitoxin

Source ID Structure

References