Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
Location | 447650..448283 | Replicon | chromosome |
Accession | NZ_CP013314 | ||
Organism | Vibrio cholerae strain E9120 |
Toxin (Protein)
Gene name | higB | Uniprot ID | Q9KMA6 |
Locus tag | ASZ79_RS16860 | Protein ID | WP_000843587.1 |
Coordinates | 447650..447982 (+) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | ASZ79_RS16865 | Protein ID | WP_000071008.1 |
Coordinates | 447969..448283 (+) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ASZ79_RS20925 | 443091..443294 | + | 204 | WP_001911745.1 | hypothetical protein | - |
ASZ79_RS20735 | 443575..443748 | + | 174 | WP_001882305.1 | DUF3709 domain-containing protein | - |
ASZ79_RS16800 | 444108..444377 | + | 270 | WP_001198131.1 | hypothetical protein | - |
ASZ79_RS21085 | 444695..444866 | + | 172 | Protein_486 | DUF645 family protein | - |
ASZ79_RS16815 | 445075..445461 | + | 387 | WP_000703163.1 | VOC family protein | - |
ASZ79_RS16820 | 445663..445905 | + | 243 | WP_000107461.1 | hypothetical protein | - |
ASZ79_RS16825 | 446076..446453 | + | 378 | WP_000411109.1 | hypothetical protein | - |
ASZ79_RS21050 | 446510..446624 | + | 115 | Protein_490 | acetyltransferase | - |
ASZ79_RS16830 | 446573..446854 | + | 282 | WP_001894453.1 | DUF1289 domain-containing protein | - |
ASZ79_RS16845 | 447020..447133 | + | 114 | WP_001889158.1 | hypothetical protein | - |
ASZ79_RS16850 | 447082..447309 | + | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
ASZ79_RS16860 | 447650..447982 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
ASZ79_RS16865 | 447969..448283 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
ASZ79_RS16870 | 448420..448854 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
ASZ79_RS20835 | 449022..449177 | + | 156 | WP_000751734.1 | hypothetical protein | - |
ASZ79_RS16885 | 449302..450282 | - | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
ASZ79_RS16890 | 450350..450656 | + | 307 | Protein_499 | CatB-related O-acetyltransferase | - |
ASZ79_RS16895 | 450793..451485 | + | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
ASZ79_RS16900 | 451485..451886 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
ASZ79_RS20750 | 451856..451999 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
ASZ79_RS16910 | 452074..452487 | + | 414 | WP_000049417.1 | VOC family protein | - |
ASZ79_RS16915 | 452701..452952 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
ASZ79_RS16920 | 452942..453229 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 304700..468464 | 163764 | |
inside | Integron | - | - | 309780..468088 | 158308 | ||
flank | IS/Tn | - | - | 449302..450282 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T58362 WP_000843587.1 NZ_CP013314:447650-447982 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T58362 NZ_CP013314:447650-447982 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT58362 WP_000071008.1 NZ_CP013314:447969-448283 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT58362 NZ_CP013314:447969-448283 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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