199009

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 388213..388979 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag KAF59_RS15840 Protein ID WP_000982260.1
Coordinates 388213..388710 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag KAF59_RS15845 Protein ID WP_000246253.1
Coordinates 388707..388979 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS15795 (KAF59_15795) 384075..384381 + 307 Protein_404 CatB-related O-acetyltransferase -
KAF59_RS18900 384518..384916 + 399 Protein_405 GNAT family N-acetyltransferase -
KAF59_RS18905 385040..385210 + 171 WP_001080654.1 hypothetical protein -
KAF59_RS15805 (KAF59_15805) 385210..385611 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
KAF59_RS15810 (KAF59_15810) 385614..385724 + 111 WP_082798255.1 DUF3265 domain-containing protein -
KAF59_RS15815 (KAF59_15815) 385799..386212 + 414 WP_000049417.1 VOC family protein -
KAF59_RS15820 (KAF59_15820) 386426..386677 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KAF59_RS15825 (KAF59_15825) 386667..386954 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAF59_RS15830 (KAF59_15830) 387082..387537 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
KAF59_RS18910 387594..387716 + 123 Protein_413 acetyltransferase -
KAF59_RS15835 (KAF59_15835) 387887..388011 + 125 Protein_414 DUF645 family protein -
KAF59_RS18915 388128..388196 + 69 Protein_415 acetyltransferase -
KAF59_RS15840 (KAF59_15840) 388213..388710 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
KAF59_RS15845 (KAF59_15845) 388707..388979 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
KAF59_RS18920 389131..389193 + 63 Protein_418 acetyltransferase -
KAF59_RS15850 (KAF59_15850) 389210..389878 + 669 WP_000043871.1 hypothetical protein -
KAF59_RS15855 (KAF59_15855) 390030..390317 + 288 WP_000426470.1 hypothetical protein -
KAF59_RS15860 (KAF59_15860) 390458..390829 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
KAF59_RS18925 391052..391321 + 270 WP_000179600.1 DUF1778 domain-containing protein -
KAF59_RS15870 (KAF59_15870) 391318..391851 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
KAF59_RS18930 391861..391971 + 111 WP_086010065.1 DUF3265 domain-containing protein -
KAF59_RS15875 (KAF59_15875) 392053..392310 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KAF59_RS15880 (KAF59_15880) 392298..392600 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAF59_RS15885 (KAF59_15885) 392834..393751 + 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805
flank IS/Tn - - 383027..384007 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T199009 WP_000982260.1 NZ_CP072850:c388710-388213 [Vibrio cholerae MO10]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T199009 NZ_CP097102:c2457374-2457072 [Halomonas venusta]
ATGGCTGAAGTAATTTGGACAGAGCCTGCCCTTCAAGAACTGGATGCCATCGCTGAGTACATTGCTCTGGATAATCCTGC
TGCCGCAAGCCATCTGGTCCAAGACGTTTTCGATAAGACCGAGCGTTTGGAAAATTTCCCCCGATCTGGACGGATTCCTC
CTGAGCTCCCCAATTCGGTATACAGGGAGATAGTGGTTCCACCATGTCGCATTTTTTATCGTGAGGATGAGAAACAGGTT
CTGATCCTTTATGTTATGCGAGAGGAGCGGCAGCTTCGTGCGTACATGCTTGGGAATAGCTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT199009 WP_000246253.1 NZ_CP072850:c388979-388707 [Vibrio cholerae MO10]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT199009 NZ_CP097102:c2457619-2457362 [Halomonas venusta]
ATGAAAGTTGAACTTGTTACCAACCTTAAGCGCCAAGCCACAAAAATCTTGGCAGACCTGCATCTTTCGAAAGAGCCGGT
ACTGATCACTGAACATGGCAAGCCATCCGCATACCTTGTTGATGTGCAAGATTACGAGTTTATGCAGCGCCGACTAGAGC
TGCTTGAGGGGCTTGCGCGGGGAGAGCGCGCTGTACTTGAGGGAAGAACGTACAGCCAAAGCGAGGCCAGGGAGAAAATG
AGTAAATGGCTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References