45810

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 374671..375199 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag N900_RS15865 Protein ID WP_000221352.1
Coordinates 374671..374961 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag N900_RS15870 Protein ID WP_000213183.1
Coordinates 374951..375199 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N900_RS20355 369943..370053 + 111 WP_134814058.1 DUF3265 domain-containing protein -
N900_RS20360 370230..370355 + 126 WP_001944767.1 DUF645 family protein -
N900_RS20365 370371..370409 + 39 WP_106019119.1 hypothetical protein -
N900_RS15840 370657..371625 + 969 WP_016710711.1 LD-carboxypeptidase -
N900_RS15850 372343..373272 + 930 WP_000335802.1 hypothetical protein -
N900_RS20015 373269..373379 + 111 WP_071917832.1 DUF3265 domain-containing protein -
N900_RS15855 373407..373883 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
N900_RS15860 374020..374535 + 516 WP_001201528.1 lipocalin family protein -
N900_RS15865 374671..374961 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N900_RS15870 374951..375199 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N900_RS15885 375770..376423 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
N900_RS15890 376695..377120 + 426 WP_000415748.1 hypothetical protein -
N900_RS15895 377328..377724 + 397 Protein_376 DUF3465 domain-containing protein -
N900_RS15900 377875..378405 + 531 WP_000415563.1 hypothetical protein -
N900_RS15905 378543..379043 + 501 WP_000789723.1 hypothetical protein -
N900_RS15910 379199..379597 + 399 WP_001882293.1 hypothetical protein -
N900_RS15915 379697..380161 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..411088 106443
inside Integron - - 309725..410760 101035


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T45810 WP_000221352.1 NZ_CP006948:c374961-374671 [Vibrio cholerae O1 str. KW3]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T45810 NZ_CP006948:c374961-374671 [Vibrio cholerae O1 str. KW3]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT45810 WP_000213183.1 NZ_CP006948:c375199-374951 [Vibrio cholerae O1 str. KW3]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT45810 NZ_CP006948:c375199-374951 [Vibrio cholerae O1 str. KW3]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References