Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-GNAT |
| Location | 395903..396996 | Replicon | chromosome |
| Accession | NZ_LT992489 | ||
| Organism | Vibrio cholerae strain 4295STDY6534232 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9KMA2 |
| Locus tag | DG176_RS16195 | Protein ID | WP_000351248.1 |
| Coordinates | 395903..396304 (-) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | - |
| Locus tag | DG176_RS16200 | Protein ID | WP_001047169.1 |
| Coordinates | 396304..396996 (-) | Length | 231 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DG176_RS16140 | 391197..391484 | - | 288 | WP_000426470.1 | hypothetical protein | - |
| DG176_RS16145 | 391636..392304 | - | 669 | WP_000043871.1 | hypothetical protein | - |
| DG176_RS16150 | 392535..392807 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| DG176_RS16155 | 392804..393301 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| DG176_RS16165 | 393503..393655 | - | 153 | WP_001884520.1 | DUF645 family protein | - |
| DG176_RS16170 | 393977..394432 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
| DG176_RS16175 | 394560..394847 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| DG176_RS16180 | 394837..395088 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| DG176_RS16185 | 395302..395715 | - | 414 | WP_000049417.1 | VOC family protein | - |
| DG176_RS16190 | 395790..395933 | - | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| DG176_RS16195 | 395903..396304 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| DG176_RS16200 | 396304..396996 | - | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | Antitoxin |
| DG176_RS16205 | 397133..397439 | - | 307 | Protein_349 | CatB-related O-acetyltransferase | - |
| DG176_RS16210 | 397507..398487 | + | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
| DG176_RS19665 | 398612..398767 | - | 156 | WP_000751734.1 | hypothetical protein | - |
| DG176_RS16215 | 398935..399369 | - | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
| DG176_RS16220 | 399506..399820 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | - |
| DG176_RS16225 | 399807..400139 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| DG176_RS16235 | 400480..400707 | - | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
| DG176_RS19790 | 400656..400769 | - | 114 | WP_001889158.1 | hypothetical protein | - |
| DG176_RS16255 | 400935..401216 | - | 282 | WP_001894453.1 | DUF1289 domain-containing protein | - |
| DG176_RS19795 | 401165..401279 | - | 115 | Protein_358 | acetyltransferase | - |
| DG176_RS16260 | 401336..401713 | - | 378 | WP_000411109.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 379325..476297 | 96972 | |
| flank | IS/Tn | - | - | 397507..398487 | 980 | ||
| inside | Integron | catB9 | - | 379701..469509 | 89808 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14608.71 Da Isoelectric Point: 4.0128
>T294375 WP_000351248.1 NZ_LT992489:c396304-395903 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
Antitoxin
Download Length: 231 a.a. Molecular weight: 26352.73 Da Isoelectric Point: 8.5633
>AT294375 WP_001047169.1 NZ_LT992489:c396996-396304 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 693 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|