Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 399845..400800 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag N900_RS16075 Protein ID WP_000118351.1
Coordinates 400267..400800 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag N900_RS16070 Protein ID WP_001882332.1
Coordinates 399845..400270 (+) Length 142 a.a.

Genomic Context

N900_RS16025N900_RS16030N900_RS16035N900_RS16040N900_RS16055N900_RS16060N900_RS16065N900_RS16070N900_RS16075N900_RS16080N900_RS16085N900_RS16090N900_RS16095N900_RS16100N900_RS16105N900_RS16110N900_RS16115N900_RS16045N900_RS16050
Location: 395375..395626 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 395616..395903 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 396031..396486 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 396808..396960 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 398159..398827 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 398979..399266 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 399407..399778 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 399845..400270 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 400267..400800 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 401002..401259 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 401247..401549 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 401783..402699 (917 bp)
Type: Others
Protein ID: Protein_421
Location: 402856..403245 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 403381..403590 (210 bp)
Type: Others
Protein ID: Protein_423
Location: 403709..404146 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 404210..404428 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 404603..405475 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 397162..397659 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 397656..397928 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N900_RS16025395375..395626+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
N900_RS16030395616..395903+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
N900_RS16035396031..396486+456WP_001245327.1GNAT family N-acetyltransferase-
N900_RS16040396808..396960+153WP_001884520.1DUF645 family protein-
N900_RS16045397162..397659-498WP_000982260.1GNAT family N-acetyltransferase-
N900_RS16050397656..397928-273WP_000246253.1DUF1778 domain-containing protein-
N900_RS16055398159..398827+669WP_000043871.1hypothetical protein-
N900_RS16060398979..399266+288WP_000426470.1hypothetical protein-
N900_RS16065399407..399778+372WP_001164080.1nucleotide pyrophosphohydrolase-
N900_RS16070399845..400270+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
N900_RS16075400267..400800+534WP_000118351.1GNAT family N-acetyltransferaseToxin
N900_RS16080401002..401259+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
N900_RS16085401247..401549+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
N900_RS16090401783..402699+917Protein_421alpha/beta hydrolase-
N900_RS16095402856..403245+390WP_001081302.1hypothetical protein-
N900_RS16100403381..403590+210Protein_423GNAT family N-acetyltransferase-
N900_RS16105403709..404146+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
N900_RS16110404210..404428+219WP_071908318.1GNAT family N-acetyltransferase-
N900_RS16115404603..405475+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..411088106443
insideIntegron--309725..410760101035
flankIS/Tn--403709..404146437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T45815 WP_000118351.1 NZ_CP006948:400267-400800 [Vibrio cholerae O1 str. KW3]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T45815 NZ_CP006948:400267-400800 [Vibrio cholerae O1 str. KW3]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT45815 WP_001882332.1 NZ_CP006948:399845-400270 [Vibrio cholerae O1 str. KW3]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT45815 NZ_CP006948:399845-400270 [Vibrio cholerae O1 str. KW3]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References