Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 855824..856457 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag LZM82_RS17430 Protein ID WP_000843587.1
Coordinates 856125..856457 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZM82_RS17425 Protein ID WP_000071008.1
Coordinates 855824..856138 (-) Length 105 a.a.

Genomic Context

LZM82_RS17410LZM82_RS17370LZM82_RS17375LZM82_RS17380LZM82_RS17385LZM82_RS17390LZM82_RS17395LZM82_RS17400LZM82_RS17405LZM82_RS17415LZM82_RS17420LZM82_RS17425LZM82_RS17430LZM82_RS17435LZM82_RS17440LZM82_RS17445LZM82_RS17450LZM82_RS17455LZM82_RS17460LZM82_RS17465LZM82_RS17470LZM82_RS18760LZM82_RS17475LZM82_RS17480LZM82_RS17485LZM82_RS18765
Location: 853825..854805 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 850878..851165 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 851155..851406 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 851620..852033 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 852108..852218 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 852221..852622 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 852622..852792 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 852916..853314 (399 bp)
Type: Others
Protein ID: Protein_746
Location: 853451..853757 (307 bp)
Type: Others
Protein ID: Protein_747
Location: 854930..855085 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 855253..855687 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 855824..856138 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 856125..856457 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 856798..857025 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 856974..857087 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 857253..857474 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 857483..857597 (115 bp)
Type: Others
Protein ID: Protein_756
Location: 857654..858031 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 858202..858561 (360 bp)
Type: Others
Protein ID: WP_226979446.1
Location: 858646..859032 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 859241..859373 (133 bp)
Type: Others
Protein ID: Protein_760
Location: 859364..859489 (126 bp)
Type: Others
Protein ID: WP_080360924.1
Location: 859730..859999 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 860359..860556 (198 bp)
Type: Others
Protein ID: WP_001894451.1
Location: 860813..861016 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 861157..861222 (66 bp)
Type: Others
Protein ID: Protein_765
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZM82_RS17370 (LZM82_17370)850878..851165-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
LZM82_RS17375 (LZM82_17375)851155..851406-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
LZM82_RS17380 (LZM82_17380)851620..852033-414WP_000049417.1VOC family protein-
LZM82_RS17385 (LZM82_17385)852108..852218-111WP_082798255.1DUF3265 domain-containing protein-
LZM82_RS17390 (LZM82_17390)852221..852622-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
LZM82_RS17395 (LZM82_17395)852622..852792-171WP_001080654.1hypothetical protein-
LZM82_RS17400 (LZM82_17400)852916..853314-399Protein_746GNAT family N-acetyltransferase-
LZM82_RS17405 (LZM82_17405)853451..853757-307Protein_747CatB-related O-acetyltransferase-
LZM82_RS17410 (LZM82_17410)853825..854805+981WP_000019370.1IS5-like element ISVch5 family transposase-
LZM82_RS17415 (LZM82_17415)854930..855085-156WP_000751734.1hypothetical protein-
LZM82_RS17420 (LZM82_17420)855253..855687-435WP_000256036.1GNAT family N-acetyltransferase-
LZM82_RS17425 (LZM82_17425)855824..856138-315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
LZM82_RS17430 (LZM82_17430)856125..856457-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LZM82_RS17435 (LZM82_17435)856798..857025-228WP_073426587.1DUF1289 domain-containing protein-
LZM82_RS17440 (LZM82_17440)856974..857087-114WP_001889158.1hypothetical protein-
LZM82_RS17445 (LZM82_17445)857253..857474-222WP_032468461.1DUF1289 domain-containing protein-
LZM82_RS17450 (LZM82_17450)857483..857597-115Protein_756acetyltransferase-
LZM82_RS17455 (LZM82_17455)857654..858031-378WP_000411109.1hypothetical protein-
LZM82_RS17460 (LZM82_17460)858202..858561-360WP_226979446.1pullulanase-
LZM82_RS17465 (LZM82_17465)858646..859032-387WP_000703163.1VOC family protein-
LZM82_RS17470 (LZM82_17470)859241..859373-133Protein_760DUF645 family protein-
LZM82_RS18760859364..859489-126WP_080360924.1general secretion pathway protein GspH-
LZM82_RS17475 (LZM82_17475)859730..859999-270WP_001198131.1hypothetical protein-
LZM82_RS17480 (LZM82_17480)860359..860556-198WP_001894451.1DUF3709 domain-containing protein-
LZM82_RS17485 (LZM82_17485)860813..861016-204WP_001911745.1hypothetical protein-
LZM82_RS18765861157..861222-66Protein_765acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-835643..943910108267
insideIntegron--836019..937068101049
flankIS/Tn--853825..854805980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T230642 WP_000843587.1 NZ_CP090400:c856457-856125 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T230642 NZ_CP125222:16355-16636 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT230642 WP_000071008.1 NZ_CP090400:c856138-855824 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT230642 NZ_CP125222:16114-16365 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References