230642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 855824..856457 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag LZM82_RS17430 Protein ID WP_000843587.1
Coordinates 856125..856457 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZM82_RS17425 Protein ID WP_000071008.1
Coordinates 855824..856138 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17370 (LZM82_17370) 850878..851165 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZM82_RS17375 (LZM82_17375) 851155..851406 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LZM82_RS17380 (LZM82_17380) 851620..852033 - 414 WP_000049417.1 VOC family protein -
LZM82_RS17385 (LZM82_17385) 852108..852218 - 111 WP_082798255.1 DUF3265 domain-containing protein -
LZM82_RS17390 (LZM82_17390) 852221..852622 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
LZM82_RS17395 (LZM82_17395) 852622..852792 - 171 WP_001080654.1 hypothetical protein -
LZM82_RS17400 (LZM82_17400) 852916..853314 - 399 Protein_746 GNAT family N-acetyltransferase -
LZM82_RS17405 (LZM82_17405) 853451..853757 - 307 Protein_747 CatB-related O-acetyltransferase -
LZM82_RS17410 (LZM82_17410) 853825..854805 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
LZM82_RS17415 (LZM82_17415) 854930..855085 - 156 WP_000751734.1 hypothetical protein -
LZM82_RS17420 (LZM82_17420) 855253..855687 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
LZM82_RS17425 (LZM82_17425) 855824..856138 - 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
LZM82_RS17430 (LZM82_17430) 856125..856457 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZM82_RS17435 (LZM82_17435) 856798..857025 - 228 WP_073426587.1 DUF1289 domain-containing protein -
LZM82_RS17440 (LZM82_17440) 856974..857087 - 114 WP_001889158.1 hypothetical protein -
LZM82_RS17445 (LZM82_17445) 857253..857474 - 222 WP_032468461.1 DUF1289 domain-containing protein -
LZM82_RS17450 (LZM82_17450) 857483..857597 - 115 Protein_756 acetyltransferase -
LZM82_RS17455 (LZM82_17455) 857654..858031 - 378 WP_000411109.1 hypothetical protein -
LZM82_RS17460 (LZM82_17460) 858202..858561 - 360 WP_226979446.1 pullulanase -
LZM82_RS17465 (LZM82_17465) 858646..859032 - 387 WP_000703163.1 VOC family protein -
LZM82_RS17470 (LZM82_17470) 859241..859373 - 133 Protein_760 DUF645 family protein -
LZM82_RS18760 859364..859489 - 126 WP_080360924.1 general secretion pathway protein GspH -
LZM82_RS17475 (LZM82_17475) 859730..859999 - 270 WP_001198131.1 hypothetical protein -
LZM82_RS17480 (LZM82_17480) 860359..860556 - 198 WP_001894451.1 DUF3709 domain-containing protein -
LZM82_RS17485 (LZM82_17485) 860813..861016 - 204 WP_001911745.1 hypothetical protein -
LZM82_RS18765 861157..861222 - 66 Protein_765 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049
flank IS/Tn - - 853825..854805 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T230642 WP_000843587.1 NZ_CP090400:c856457-856125 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T230642 NZ_CP125222:16355-16636 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT230642 WP_000071008.1 NZ_CP090400:c856138-855824 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT230642 NZ_CP125222:16114-16365 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References