Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 324225..324784 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GPY07_RS15725 Protein ID WP_000578476.1
Coordinates 324506..324784 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GPY07_RS15720 Protein ID WP_000381183.1
Coordinates 324225..324509 (+) Length 95 a.a.

Genomic Context

GPY07_RS15720GPY07_RS15725GPY07_RS15710GPY07_RS15715GPY07_RS15730GPY07_RS15740GPY07_RS15745GPY07_RS15750GPY07_RS15755GPY07_RS15760GPY07_RS15765GPY07_RS15770GPY07_RS15775
Location: 324225..324509 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 324506..324784 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 322919..323332 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 323516..324031 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 324923..325318 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 325569..325694 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 325993..326514 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 326508..326777 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 326808..326912 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 326969..327568 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 327718..328590 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 328765..328983 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 329047..329484 (438 bp)
Type: Others
Protein ID: WP_000503169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY07_RS15710322919..323332-414WP_000049420.1VOC family protein-
GPY07_RS15715323516..324031-516WP_000343779.1GNAT family N-acetyltransferase-
GPY07_RS15720324225..324509+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GPY07_RS15725324506..324784+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
GPY07_RS15730324923..325318-396WP_001000867.1hypothetical protein-
GPY07_RS15740325569..325694-126WP_001905700.1DUF645 family protein-
GPY07_RS15745325993..326514-522WP_000921691.1DUF2442 domain-containing protein-
GPY07_RS15750326508..326777-270WP_001114075.1DUF4160 domain-containing protein-
GPY07_RS15755326808..326912-105WP_099607150.1acetyltransferase-
GPY07_RS15760326969..327568-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GPY07_RS15765327718..328590-873WP_000254716.1DUF3800 domain-containing protein-
GPY07_RS15770328765..328983-219WP_071908318.1GNAT family N-acetyltransferase-
GPY07_RS15775329047..329484-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-322056..41902496968
insideIntegron--322432..41223689804
flankIS/Tn--329047..329484437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145056 WP_000578476.1 NZ_CP046841:324506-324784 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145056 NZ_CP062251:c5179451-5179107 [Pseudomonas sp. IzPS59]
ATGAGAACAATATTCTTTGAAACCACTCTGTTCACCGCAAACCTGGGTCATTACCTCACGGACGACGAATATCGTGAGCT
ACAGACCTACATGCAGAGCAATCCGCATGCGGGCGATGTCATGCCTCGAACCGGTGGCTTCCGAAAACTGCGTTGGGCGG
ATGCTCGTCGTGGTAAAGGCAGGCGAGGCGGCTTGCGAGTTATCTATTATTGGCTTATGAATGATGGCCAGTTTTGGATG
TTTGCGATTTATGACAAAGATGAGCTTGAGAATTTGACCGCCGATCAAGAGAGGGCGCTCAAGGGAGCCATAGAGAAAGA
GTTGAAAACACGAGGTACCCCATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145056 WP_000381183.1 NZ_CP046841:324225-324509 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145056 NZ_CP062251:c5179110-5178796 [Pseudomonas sp. IzPS59]
ATGAAAAAACGCGACCTGTTTGCAGAATTGATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAAGGAAAAATCACGCT
ACGTAATACGACGCTTGAGGACAAACCAGCCCCCGAAGTCGGTGCTCAGGAAATCGTAGCGTTACGGGAAAAACTGCACA
TGTCACAGGCCGTTTTTGCCAGAAGAATCAGGACAAGTCCAAGCACCCTTAGAAACTGGGAGCAGGAGAAATCAAAGCCC
AACGCTCAGGCTGCCTTGCTGATCCGTTTGGTGGAAAAATTCCCTGATATGGTCGAGCGATTGAGCGCTGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References