145056

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 324225..324784 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GPY07_RS15725 Protein ID WP_000578476.1
Coordinates 324506..324784 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GPY07_RS15720 Protein ID WP_000381183.1
Coordinates 324225..324509 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS15710 322919..323332 - 414 WP_000049420.1 VOC family protein -
GPY07_RS15715 323516..324031 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
GPY07_RS15720 324225..324509 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPY07_RS15725 324506..324784 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPY07_RS15730 324923..325318 - 396 WP_001000867.1 hypothetical protein -
GPY07_RS15740 325569..325694 - 126 WP_001905700.1 DUF645 family protein -
GPY07_RS15745 325993..326514 - 522 WP_000921691.1 DUF2442 domain-containing protein -
GPY07_RS15750 326508..326777 - 270 WP_001114075.1 DUF4160 domain-containing protein -
GPY07_RS15755 326808..326912 - 105 WP_099607150.1 acetyltransferase -
GPY07_RS15760 326969..327568 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GPY07_RS15765 327718..328590 - 873 WP_000254716.1 DUF3800 domain-containing protein -
GPY07_RS15770 328765..328983 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
GPY07_RS15775 329047..329484 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804
flank IS/Tn - - 329047..329484 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145056 WP_000578476.1 NZ_CP046841:324506-324784 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145056 NZ_CP062251:c5179451-5179107 [Pseudomonas sp. IzPS59]
ATGAGAACAATATTCTTTGAAACCACTCTGTTCACCGCAAACCTGGGTCATTACCTCACGGACGACGAATATCGTGAGCT
ACAGACCTACATGCAGAGCAATCCGCATGCGGGCGATGTCATGCCTCGAACCGGTGGCTTCCGAAAACTGCGTTGGGCGG
ATGCTCGTCGTGGTAAAGGCAGGCGAGGCGGCTTGCGAGTTATCTATTATTGGCTTATGAATGATGGCCAGTTTTGGATG
TTTGCGATTTATGACAAAGATGAGCTTGAGAATTTGACCGCCGATCAAGAGAGGGCGCTCAAGGGAGCCATAGAGAAAGA
GTTGAAAACACGAGGTACCCCATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145056 WP_000381183.1 NZ_CP046841:324225-324509 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145056 NZ_CP062251:c5179110-5178796 [Pseudomonas sp. IzPS59]
ATGAAAAAACGCGACCTGTTTGCAGAATTGATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAAGGAAAAATCACGCT
ACGTAATACGACGCTTGAGGACAAACCAGCCCCCGAAGTCGGTGCTCAGGAAATCGTAGCGTTACGGGAAAAACTGCACA
TGTCACAGGCCGTTTTTGCCAGAAGAATCAGGACAAGTCCAAGCACCCTTAGAAACTGGGAGCAGGAGAAATCAAAGCCC
AACGCTCAGGCTGCCTTGCTGATCCGTTTGGTGGAAAAATTCCCTGATATGGTCGAGCGATTGAGCGCTGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References