199010

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 391052..391851 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag KAF59_RS15870 Protein ID WP_000118351.1
Coordinates 391318..391851 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag KAF59_RS18925 Protein ID WP_000179600.1
Coordinates 391052..391321 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS15820 (KAF59_15820) 386426..386677 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KAF59_RS15825 (KAF59_15825) 386667..386954 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAF59_RS15830 (KAF59_15830) 387082..387537 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
KAF59_RS18910 387594..387716 + 123 Protein_413 acetyltransferase -
KAF59_RS15835 (KAF59_15835) 387887..388011 + 125 Protein_414 DUF645 family protein -
KAF59_RS18915 388128..388196 + 69 Protein_415 acetyltransferase -
KAF59_RS15840 (KAF59_15840) 388213..388710 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
KAF59_RS15845 (KAF59_15845) 388707..388979 - 273 WP_000246253.1 DUF1778 domain-containing protein -
KAF59_RS18920 389131..389193 + 63 Protein_418 acetyltransferase -
KAF59_RS15850 (KAF59_15850) 389210..389878 + 669 WP_000043871.1 hypothetical protein -
KAF59_RS15855 (KAF59_15855) 390030..390317 + 288 WP_000426470.1 hypothetical protein -
KAF59_RS15860 (KAF59_15860) 390458..390829 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
KAF59_RS18925 391052..391321 + 270 WP_000179600.1 DUF1778 domain-containing protein Antitoxin
KAF59_RS15870 (KAF59_15870) 391318..391851 + 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
KAF59_RS18930 391861..391971 + 111 WP_086010065.1 DUF3265 domain-containing protein -
KAF59_RS15875 (KAF59_15875) 392053..392310 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KAF59_RS15880 (KAF59_15880) 392298..392600 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAF59_RS15885 (KAF59_15885) 392834..393751 + 918 WP_000186333.1 alpha/beta hydrolase -
KAF59_RS15890 (KAF59_15890) 393908..394297 + 390 WP_001081302.1 hypothetical protein -
KAF59_RS15895 (KAF59_15895) 394433..394642 + 210 Protein_429 GNAT family N-acetyltransferase -
KAF59_RS15900 (KAF59_15900) 394761..395198 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
KAF59_RS15905 (KAF59_15905) 395259..395480 + 222 Protein_431 GNAT family N-acetyltransferase -
KAF59_RS15910 (KAF59_15910) 395655..396527 + 873 WP_000254716.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805
flank IS/Tn - - 394761..395198 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T199010 WP_000118351.1 NZ_CP072850:391318-391851 [Vibrio cholerae MO10]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T199010 NZ_CP097103:334011-334253 [Pseudomonas sp. NY11382]
CTGCGGGATCCGCGGGCGAAAGCTCGCATAAACGCCCGGTTGCGGCGGTTGGAGCTCGGAGTGAAGGGTGACTGTAAGCC
AGTTGCTGAGGGGGTGTCCGAGCTTCGGGTCGATTATGGTCCGGGCTATCGGGTGTATTTCGTTCAGCGAGGTTATGAAG
TGATCATCCTTCTGGCAGGTGGCGACAAATCTAGCCAAGCCAGGGATATCAAATCTGCGCTCAAGCTGGCTCGTGACCTC
TAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT199010 WP_000179600.1 NZ_CP072850:391052-391321 [Vibrio cholerae MO10]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT199010 NZ_CP097103:334263-334565 [Pseudomonas sp. NY11382]
ATGACAAACATCAAACTGACCAAATGGGACGCTGTGGACCATTTGAAAACTGAAGAGGACATGGCCTTGTACCTTGAGGC
CTGTCTGGAGGAAAACGACCCTGCACTGCTCGCTGCTGCCTTGGGTGATATCGCTCGCGCTCGTGGTATGGCTCAGTTGG
CACGTGATACTGGGCTCACGCGGGAAGGGTTGTACAAGGCCTTGTCTGCTGAAGGTAATCCGAGCCTGGCGACCATCATG
AAGGTAATGGCGGCGCTTGGCGTTCGGCTCCATGCCGAAGTGCTGCCACGCTCAGTGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM94

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UER4

References