38669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 216680..217464 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag K6J80_RS14820 Protein ID WP_001114075.1
Coordinates 217195..217464 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag K6J80_RS14815 Protein ID WP_000921691.1
Coordinates 216680..217201 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS14785 213606..214019 - 414 WP_000049420.1 VOC family protein -
K6J80_RS14790 214203..214718 - 516 WP_000343779.1 GNAT family protein -
K6J80_RS14795 214912..215196 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
K6J80_RS14800 215193..215471 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
K6J80_RS14805 215610..216005 - 396 WP_001000867.1 hypothetical protein -
K6J80_RS14810 216256..216381 - 126 WP_001905700.1 DUF645 family protein -
K6J80_RS14815 216680..217201 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
K6J80_RS14820 217195..217464 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
K6J80_RS14825 217531..217599 - 69 Protein_190 acetyltransferase -
K6J80_RS14830 217656..218255 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
K6J80_RS14835 218405..219277 - 873 WP_000254716.1 DUF3800 domain-containing protein -
K6J80_RS14840 219452..219673 - 222 Protein_193 GNAT family N-acetyltransferase -
K6J80_RS14845 219734..220171 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
K6J80_RS14850 220290..220499 - 210 Protein_195 GNAT family N-acetyltransferase -
K6J80_RS14855 220635..221024 - 390 WP_001081302.1 hypothetical protein -
K6J80_RS14860 221181..222098 - 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737
flank IS/Tn - - 219734..220171 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T38669 WP_001114075.1 NZ_AP024554:c217464-217195 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T38669 NZ_AP024554:c217464-217195 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT38669 WP_000921691.1 NZ_AP024554:c217201-216680 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT38669 NZ_AP024554:c217201-216680 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References