Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 162703..163231 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag EEL44_RS00935 Protein ID WP_000221352.1
Coordinates 162941..163231 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag EEL44_RS00930 Protein ID WP_000213183.1
Coordinates 162703..162951 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS00880 157742..158206 + 465 WP_000140244.1 hypothetical protein -
EEL44_RS00885 158306..158704 - 399 WP_001882293.1 hypothetical protein -
EEL44_RS00895 158860..159360 - 501 WP_000789723.1 hypothetical protein -
EEL44_RS00900 159498..160028 - 531 WP_000415563.1 hypothetical protein -
EEL44_RS00905 160179..160574 - 396 WP_000649527.1 DUF3465 domain-containing protein -
EEL44_RS00910 160782..161207 - 426 WP_000415748.1 hypothetical protein -
EEL44_RS00915 161479..162132 - 654 WP_000036957.1 site-specific DNA-methyltransferase -
EEL44_RS00930 162703..162951 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EEL44_RS00935 162941..163231 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EEL44_RS00940 163367..163882 - 516 WP_001201528.1 lipocalin family protein -
EEL44_RS00945 164019..164495 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
EEL44_RS00950 164523..164633 - 111 WP_071917832.1 DUF3265 domain-containing protein -
EEL44_RS00955 164630..165559 - 930 WP_000335802.1 hypothetical protein -
EEL44_RS00960 165679..166125 - 447 WP_000128977.1 hypothetical protein -
EEL44_RS00965 166278..167282 - 1005 WP_000964925.1 LD-carboxypeptidase -
EEL44_RS00970 167495..167533 - 39 WP_106019119.1 hypothetical protein -
EEL44_RS00975 167549..167674 - 126 WP_001944767.1 DUF645 family protein -
EEL44_RS21145 167851..167961 - 111 WP_134814058.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 126763..233717 106954
inside Integron - - 127139..226875 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T113803 WP_000221352.1 NZ_CP033513:162941-163231 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T113803 NZ_CP033513:162941-163231 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT113803 WP_000213183.1 NZ_CP033513:162703-162951 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT113803 NZ_CP033513:162703-162951 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References