Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 162703..163231 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag EEL44_RS00935 Protein ID WP_000221352.1
Coordinates 162941..163231 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag EEL44_RS00930 Protein ID WP_000213183.1
Coordinates 162703..162951 (+) Length 83 a.a.

Genomic Context

EEL44_RS00880EEL44_RS00930EEL44_RS00935EEL44_RS00885EEL44_RS00895EEL44_RS00900EEL44_RS00905EEL44_RS00910EEL44_RS00915EEL44_RS00940EEL44_RS00945EEL44_RS00950EEL44_RS00955EEL44_RS00960EEL44_RS00965EEL44_RS00970EEL44_RS00975EEL44_RS21145
Location: 157742..158206 (465 bp)
Type: Others
Protein ID: WP_000140244.1
Location: 162703..162951 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 162941..163231 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 158306..158704 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 158860..159360 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 159498..160028 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 160179..160574 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 160782..161207 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 161479..162132 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 163367..163882 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 164019..164495 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 164523..164633 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 164630..165559 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 165679..166125 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 166278..167282 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 167495..167533 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 167549..167674 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 167851..167961 (111 bp)
Type: Others
Protein ID: WP_134814058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EEL44_RS00880157742..158206+465WP_000140244.1hypothetical protein-
EEL44_RS00885158306..158704-399WP_001882293.1hypothetical protein-
EEL44_RS00895158860..159360-501WP_000789723.1hypothetical protein-
EEL44_RS00900159498..160028-531WP_000415563.1hypothetical protein-
EEL44_RS00905160179..160574-396WP_000649527.1DUF3465 domain-containing protein-
EEL44_RS00910160782..161207-426WP_000415748.1hypothetical protein-
EEL44_RS00915161479..162132-654WP_000036957.1site-specific DNA-methyltransferase-
EEL44_RS00930162703..162951+249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
EEL44_RS00935162941..163231+291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EEL44_RS00940163367..163882-516WP_001201528.1lipocalin family protein-
EEL44_RS00945164019..164495-477WP_001047180.1GNAT family N-acetyltransferase-
EEL44_RS00950164523..164633-111WP_071917832.1DUF3265 domain-containing protein-
EEL44_RS00955164630..165559-930WP_000335802.1hypothetical protein-
EEL44_RS00960165679..166125-447WP_000128977.1hypothetical protein-
EEL44_RS00965166278..167282-1005WP_000964925.1LD-carboxypeptidase-
EEL44_RS00970167495..167533-39WP_106019119.1hypothetical protein-
EEL44_RS00975167549..167674-126WP_001944767.1DUF645 family protein-
EEL44_RS21145167851..167961-111WP_134814058.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-126763..233717106954
insideIntegron--127139..22687599736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T113803 WP_000221352.1 NZ_CP033513:162941-163231 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T113803 NZ_CP033513:162941-163231 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT113803 WP_000213183.1 NZ_CP033513:162703-162951 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT113803 NZ_CP033513:162703-162951 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References