Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 453979..454745 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag DG176_RS16830 Protein ID WP_000982260.1
Coordinates 454248..454745 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag DG176_RS16825 Protein ID WP_000246253.1
Coordinates 453979..454251 (+) Length 91 a.a.

Genomic Context

DG176_RS16795DG176_RS16800DG176_RS16825DG176_RS16830DG176_RS16870DG176_RS16875DG176_RS16755DG176_RS16760DG176_RS16765DG176_RS16770DG176_RS16775DG176_RS16780DG176_RS16785DG176_RS16805DG176_RS16815DG176_RS16820DG176_RS16835DG176_RS16840DG176_RS16855DG176_RS16860DG176_RS16865DG176_RS16885DG176_RS16890
Location: 452077..452355 (279 bp)
Type: Others
Protein ID: WP_001258569.1
Location: 452348..452617 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 453979..454251 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 454248..454745 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 457371..457613 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 457632..457949 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 449476..449718 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 449810..449959 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 449932..450183 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 450378..450764 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 450754..450855 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 451055..451261 (207 bp)
Type: Others
Protein ID: Protein_446
Location: 451513..451791 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 452765..453211 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 453407..453445 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 453461..453586 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 454895..455410 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 455547..456083 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 456341..456622 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 456571..456684 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 456741..457127 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 458103..458441 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 458599..459303 (705 bp)
Type: Others
Protein ID: WP_000087610.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG176_RS16755449476..449718-243WP_000107461.1hypothetical protein-
DG176_RS16760449810..449959-150WP_071908333.1DUF3265 domain-containing protein-
DG176_RS16765449932..450183-252WP_001890111.1TIGR03643 family protein-
DG176_RS16770450378..450764-387WP_000703163.1VOC family protein-
DG176_RS16775450754..450855-102WP_001921603.1hypothetical protein-
DG176_RS16780451055..451261-207Protein_446DUF3709 domain-containing protein-
DG176_RS16785451513..451791-279WP_001921601.1DUF3709 domain-containing protein-
DG176_RS16795452077..452355+279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
DG176_RS16800452348..452617+270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
DG176_RS16805452765..453211-447WP_000006157.1hypothetical protein-
DG176_RS16815453407..453445-39WP_106019118.1hypothetical protein-
DG176_RS16820453461..453586-126WP_001900195.1DUF645 family protein-
DG176_RS16825453979..454251+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
DG176_RS16830454248..454745+498WP_000982260.1GNAT family N-acetyltransferaseToxin
DG176_RS16835454895..455410-516WP_001201509.1lipocalin family protein-
DG176_RS16840455547..456083-537WP_000469482.1GNAT family N-acetyltransferase-
DG176_RS16855456341..456622-282WP_001894429.1DUF1289 domain-containing protein-
DG176_RS16860456571..456684-114WP_001900214.1hypothetical protein-
DG176_RS16865456741..457127-387WP_001015867.1NUDIX hydrolase-
DG176_RS16870457371..457613+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG176_RS16875457632..457949+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
DG176_RS16885458103..458441-339WP_000713853.1hypothetical protein-
DG176_RS16890458599..459303-705WP_000087610.1HNH endonuclease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-379325..47629796972
insideIntegroncatB9-379701..46950989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T294383 WP_000982260.1 NZ_LT992489:454248-454745 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT294383 WP_000246253.1 NZ_LT992489:453979-454251 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References